中枢给予下丘脑生长激素释放因子可刺激自由进食大鼠的食物摄入。

Centrally administered hypothalamic growth hormone-releasing factor stimulates food intake in free-feeding rats.

作者信息

Vaccarino F J, Feifel D, Rivier J, Vale W, Koob G F

机构信息

University of Toronto, Department of Psychology, Ontario, Canada.

出版信息

Peptides. 1988;9 Suppl 1:35-8. doi: 10.1016/0196-9781(88)90220-3.

DOI:10.1016/0196-9781(88)90220-3

PMID:2856650

Abstract

Intracerebroventricular injections of rat hypothalamic growth hormone-releasing factor (rhGRF) were examined for effects on food intake in free-feeding rats. It was found that, in picomole doses, rhGRF had a stimulatory effect on food intake. Examination of higher doses of rhGRF revealed a decrease in the facilitatory effects and an inhibitory trend at the highest dose (4 nanomoles). The present results are consistent with previous results from our laboratory showing that central injections of rhGRF stimulate food intake in food-deprived rats.

摘要

研究了向自由进食大鼠脑室内注射大鼠下丘脑生长激素释放因子（rhGRF）对食物摄入量的影响。结果发现，以皮摩尔剂量注射时，rhGRF对食物摄入量有刺激作用。对更高剂量的rhGRF进行检测发现，其促进作用减弱，在最高剂量（4纳摩尔）时呈现抑制趋势。目前的结果与我们实验室之前的结果一致，即向饥饿大鼠脑室内注射rhGRF会刺激食物摄入。