Suppr
超能文献

纤维化负担较轻对根治性切除术后肝细胞癌的长期预后有不同影响。

Less Fibrotic Burden Differently Affects the Long-Term Outcomes of Hepatocellular Carcinoma after Curative Resection.

作者信息

Lee Hye Won, Choi Gi Hong, Kim Do Young, Park Young Nyun, Kim Kyung Sik, Choi Jin Sub, Ahn Sang Hoon, Han Kwang-Hyub

机构信息

Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.

出版信息

Oncology. 2017;93(4):224-232. doi: 10.1159/000477173. Epub 2017 Jun 2.

DOI:10.1159/000477173

PMID:28571030

Abstract

BACKGROUND

The clinical features of hepatocellular carcinoma (HCC) differ in patients with and without cirrhosis.

OBJECTIVE

We aimed to investigate the long-term outcomes of noncirrhotic HCC patients after curative resection.

METHODS

We retrospectively examined 649 consecutive patients with HCC who underwent curative resection from 1996 to 2012; 387 (59.6%) were cirrhotic and 262 (40.4%) were noncirrhotic.

RESULTS

The mean age was 54.7 years, and 511 (78.7%) of the study participants were men. The most common cause of HCC was hepatitis B virus (n = 419, 64.6%). Noncirrhotic tumors were larger and more advanced than cirrhotic tumors. However, the noncirrhotic group showed better disease-free survival (DFS) and overall survival (OS) after resection than the cirrhotic group (median 64.0 vs. 56.0 months for OS and 48.0 vs. 31.0 months for DFS, p < 0.05). The predictors for HCC recurrence were cirrhosis, tumor number, portal vein invasion, and major surgery.

CONCLUSIONS

Noncirrhotic HCC showed better DFS and OS after resection than cirrhotic HCC, although noncirrhotic HCC presented more aggressively.

摘要

背景

肝细胞癌（HCC）患者有无肝硬化的临床特征有所不同。

目的

我们旨在研究根治性切除术后非肝硬化HCC患者的长期预后。

方法

我们回顾性分析了1996年至2012年期间连续接受根治性切除的649例HCC患者；其中387例（59.6%）有肝硬化，262例（40.4%）无肝硬化。

结果

研究参与者的平均年龄为54.7岁，511例（78.7%）为男性。HCC最常见的病因是乙型肝炎病毒（n = 419，64.6%）。非肝硬化肿瘤比肝硬化肿瘤更大且分期更晚。然而，非肝硬化组切除术后的无病生存期（DFS）和总生存期（OS）均优于肝硬化组（OS中位数分别为64.0个月和56.0个月，DFS中位数分别为48.0个月和31.0个月，p < 0.05）。HCC复发的预测因素为肝硬化、肿瘤数量、门静脉侵犯和大手术。