Çakir Seda, Bauters Erwin, Rivero Guadalupe, Parasote Tom, Paul Johan, Du Prez Filip E
Polymer Chemistry Research Group, Department of Organic and Macromolecular Chemistry, Ghent University , Krijgslaan 281 S4-bis, 9000 Ghent, Belgium.
FLAMAC, A division of SIM , Technologiepark 903A, 9052 Zwijnaarde, Belgium.
ACS Comb Sci. 2017 Jul 10;19(7):447-454. doi: 10.1021/acscombsci.7b00037. Epub 2017 Jun 15.
The synthesis of microcapsules via in situ polymerization is a labor-intensive and time-consuming process, where many composition and process factors affect the microcapsule formation and its morphology. Herein, we report a novel combinatorial technique for the preparation of melamine-formaldehyde microcapsules, using a custom-made and automated high-throughput platform (HTP). After performing validation experiments for ensuring the accuracy and reproducibility of the novel platform, a design of experiment study was performed. The influence of different encapsulation parameters was investigated, such as the effect of the surfactant, surfactant type, surfactant concentration and core/shell ratio. As a result, this HTP-platform is suitable to be used for the synthesis of different types of microcapsules in an automated and controlled way, allowing the screening of different reaction parameters in a shorter time compared to the manual synthetic techniques.
通过原位聚合合成微胶囊是一个劳动强度大且耗时的过程，其中许多组成和工艺因素会影响微胶囊的形成及其形态。在此，我们报告了一种使用定制的自动化高通量平台（HTP）制备三聚氰胺 - 甲醛微胶囊的新型组合技术。在进行验证实验以确保新平台的准确性和可重复性之后，开展了实验设计研究。研究了不同包封参数的影响，如表面活性剂的作用、表面活性剂类型、表面活性剂浓度和核/壳比。结果表明，该HTP平台适用于以自动化和可控的方式合成不同类型的微胶囊，与手动合成技术相比，能够在更短的时间内筛选不同的反应参数。
