综述：调节性 T 细胞在眼表的功能。
Review: The function of regulatory T cells at the ocular surface.
机构信息
Schepens Eye Research Institute, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA.
Schepens Eye Research Institute, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA.
出版信息
Ocul Surf. 2017 Oct;15(4):652-659. doi: 10.1016/j.jtos.2017.05.013. Epub 2017 May 31.
Regulatory T cells (Tregs) are critical modulators of immune homeostasis. Tregs maintain peripheral tolerance to self-antigens, thereby preventing autoimmune disease. Furthermore, Tregs suppress excessive immune responses deleterious to the host. Recent research has deepened our understanding of how Tregs function at the ocular surface. This manuscript describes the classification, the immunosuppressive mechanisms, and the phenotypic plasticity of Tregs. We review the contribution of Tregs to ocular surface autoimmune disease, as well as the function of Tregs in allergy and infection at the ocular surface. Finally, we review the role of Tregs in promoting allotolerance in corneal transplantation.
调节性 T 细胞（Tregs）是免疫稳态的关键调节剂。Tregs 维持对自身抗原的外周耐受，从而防止自身免疫性疾病。此外，Tregs 抑制对宿主有害的过度免疫反应。最近的研究加深了我们对 Tregs 在眼表面发挥功能的理解。本文描述了 Tregs 的分类、免疫抑制机制和表型可塑性。我们回顾了 Tregs 对眼表面自身免疫性疾病的贡献，以及 Tregs 在眼表面过敏和感染中的功能。最后，我们回顾了 Tregs 在促进角膜移植中同种异体耐受中的作用。
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