Ivanova A A, Maksimov V N, Ivanoshchuk D E, Orlov P S, Novoselov V P, Savchenko S V, Voevoda M I
Research Institute of Therapy and Preventive Medicine, Novosibirsk, Russia.
Novosibirsk State Medical University, Ministry of Health of the Russian Federation, Novosibirsk, Russia.
Bull Exp Biol Med. 2017 May;163(1):73-77. doi: 10.1007/s10517-017-3741-y. Epub 2017 Jun 3.
We studied association of single-nucleotide SCN5A (rs1805124), GJA5 (rs35594137), and KCNN3 (rs13376333) polymorphisms and sudden cardiac death. Humans died suddenly from cardiac causes (N=379) and unrelated sex- and age-matched control subjects were genotyped. No significant intergroup differences were found in the frequency of rs1805124 and rs13376333 genotypes and alleles. In women under 50 years, enhanced risk of sudden cardiac death was associated with rs35594137 GG genotype (OR=3.6; 95%CI=1.2-10.4; p=0.022), while in older women it was associated with rs35594137 AA genotype (OR=3.0; 95%CI=2.3-3.9; p=0.041). In women under 50 years, GA rs35594137 genotype was associated with a protective effect against sudden cardiac death (OR=0.3; 95%CI=0.1-0.8; p=0.036). Thus, GJA5 gene rs35594137 polymorphism is significantly associated with sudden cardiac death in the examined group.
我们研究了单核苷酸SCN5A（rs1805124）、GJA5（rs35594137）和KCNN3（rs13376333）多态性与心源性猝死的关联。对因心脏原因突然死亡的人（N = 379）以及与之性别和年龄匹配的无关对照受试者进行基因分型。在rs1805124和rs13376333的基因型和等位基因频率方面未发现显著的组间差异。在50岁以下女性中，rs35594137 GG基因型与心源性猝死风险增加相关（OR = 3.6；95%CI = 1.2 - 10.4；p = 0.022），而在老年女性中，rs35594137 AA基因型与之相关（OR = 3.0；95%CI = 2.3 - 3.9；p = 0.041）。在50岁以下女性中，rs35594137 GA基因型与心源性猝死具有保护作用相关（OR = 0.3；95%CI = 0.1 - 0.8；p = 0.036）。因此，在所研究的群体中，GJA5基因rs35594137多态性与心源性猝死显著相关。
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