Institute of Chemical Technology and Engineering, Poznan University of Technology, Berdychowo Str., 60-965, Poznan, Poland.
Institute of Chemical Technology and Engineering, Poznan University of Technology, Berdychowo Str., 60-965, Poznan, Poland.
Carbohydr Polym. 2017 Sep 1;171:152-162. doi: 10.1016/j.carbpol.2017.05.019. Epub 2017 May 5.
The paper presents the sorption and wettability properties for several mucoadhesive polymers (Carbopol 974P NF (carbomer polymer; carboxy polymethylene), Noveon AA-1, (polycarbophil; acrylic acid polymer crosslinked with divinyl glycol) HPMC (hypromellose; cellulose 2-hydroxyethyl methyl ester) and HEC (cellulose 2-hydroxyethyl ether) and a film-forming polymer Kollidon VA 64 (polyvinylpyrrolidone-vinyl acetate copolymer)) commonly used in controlled drug delivery systems. Moreover, the surface energy of powders was determined using the data obtained according to the three types of experimental investigation. The contact angle measurements for powders were performed according to the Washburn method and using the capillary rise technique. Whereas the sessile drop method was performed on the compressed discs of mucoadhesive polymers. For the surface characterization the IGC technique was also applied. The results obtained by different methods, for both: wettability and surface energies, were compared and correlated. The presented study showed significant differences in the morphology and surface properties of mucoadhesion polymers considered. It was confirmed that for the accurate quantification of the free surface energy (and its components), for mucoadhesive polymers considered, not only the IGC in finite concentration, but also the Washburn method should be used.
本文介绍了几种常用于控释给药系统的黏附聚合物（卡波姆 974P NF（卡波姆聚合物；羧甲基纤维素）、Noveon AA-1（聚卡波菲；与二甘醇二乙烯基醚交联的丙烯酸聚合物）、HPMC（羟丙甲纤维素；纤维素 2-羟乙基甲基醚）和 HEC（羟乙基纤维素）以及成膜聚合物聚维酮 VA64（聚乙烯吡咯烷酮-醋酸乙烯酯共聚物））的吸附和润湿性特性。此外，还使用根据三种实验研究类型获得的数据来确定粉末的表面能。粉末的接触角测量是根据 Washburn 法和毛细上升技术进行的。而在黏附聚合物的压缩片上进行了固着液滴法。对于表面特性，还应用了 IGC 技术。对两种方法（润湿性和表面能）的结果进行了比较和关联。研究表明，所考虑的黏附聚合物在形态和表面性质方面存在显著差异。研究结果证实，为了准确量化自由表面能（及其组成），对于所考虑的黏附聚合物，不仅应使用有限浓度的 IGC，还应使用 Washburn 法。
