Drug tolerance and detoxicating enzymes in Octodon degus and Wistar rats. A comparative study. - Suppr | 超能文献

Drug tolerance and detoxicating enzymes in Octodon degus and Wistar rats. A comparative study.

作者信息

Letelier M E, Del Villar E, Sanchez E

出版信息

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1985;80(1):195-8. doi: 10.1016/0742-8413(85)90154-9.

DOI:10.1016/0742-8413(85)90154-9

Abstract

Octodon degus shows greater tolerance to pentobarbital as compared with the Wistar rat. Mixed function oxidase activities in liver microsomes were higher in Octodon degus than in the Wistar rat. The reactions assayed were: aminopyrine N-demethylation, aniline and naphthalene hydroxylation and p-nitroanisole O-demethylation. These higher activities seem to be due mainly to the greater cytochrome P-450 content of liver microsomes of Octodon degus. Glutathione S-transferase activity towards 1-chloro-2,4-dinitrobenzene was 30 times higher in Octodon degus than in the Wistar rat. These results may explain the tolerance of Octodon degus to pentobarbital and other drugs.

摘要

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