Brihaye Pierre, Delpierre Isabelle, De Villé Andrée, Johansson Anne-Britt, Biarent Dominique, Mansbach Anne-Laure
University Children's Hospital Reine Fabiola, Department of ENT, Brussels, Belgium.
University Children's Hospital Reine Fabiola, Department of Neuroradiology, Brussels, Belgium.
Int J Pediatr Otorhinolaryngol. 2017 Jul;98:9-18. doi: 10.1016/j.ijporl.2017.04.022. Epub 2017 Apr 17.
To present results of a one-stage minimally invasive surgical procedure for congenital choanal atresia (CCA). Seven outcome measures were applied.
Retrospective study conducted between 1999 and 2015. The same endonasal endoscopic approach with multiflaps and no stenting was used on 36 children. The flaps were attached with fibrine glue. There were 50% unilateral and 50% bilateral cases, 70% primary and 30% secondary surgery. The mean age at primary surgery for bilateral atresia was 10 days and for unilateral atresia 4 years. Associated loco-regional disorders were: hypoplasia of the inferior turbinate, rhinopharyngeal stenosis and rhinopharyngeal web.
The average follow-up time was 6 years, ranging from 1 to 14 years. There was a functionally patent choanae in 94% of children, and 6% showed severe restenosis with a diameter less than 4 mm, which needed one revision surgery each. Charge patients were not associated with worse outcome. There was no external nasal valve stenosis and no permanent Eustachian tube dysfunction. Synechiae occurred in 3 patients with hyperplastic inferior turbinate. No patients showed any disharmonious nasal growth. In neonates with isolated bilateral CCA, breast-suction could be started within 1 day (range 1-2 days), and pain-killers were needed on average for 1.5 days (range 1-4 days). The hospital stay for unilateral isolated CCA was on average 1.5 days (range 1-2 days) and for bilateral isolated CCA, 8 days (range 3-20 days). Postoperative procedures under a short general anesthesia were necessary in 12 cases, 10 of them were infants under 6 months of age.
Surgery could be performed safely in the newborn in the early stage of life, even for unilateral atresia. Tendency for restenosis can be minimized by: 1. the construction of an as large as possible uni-neochoanae by removing the posterior part of the vomer and by drilling away the medial pterygoid; 2. in case of rhinopharyngeal stenosis, part of the endochondral clivus bone should be resected; 3. all raw surfaces should be covered by multiple mucosal flaps secured with fibrin glue; 4. no stenting; 5. appropriate postoperative care.
介绍先天性后鼻孔闭锁(CCA)一期微创手术的结果。采用了七种结果测量指标。
1999年至2015年进行的回顾性研究。对36名儿童采用相同的鼻内镜多瓣法且不进行支架置入的入路。瓣片用纤维蛋白胶固定。单侧病例占50%,双侧病例占50%;初次手术占70%,二次手术占30%。双侧闭锁初次手术的平均年龄为10天,单侧闭锁为4岁。相关的局部区域病变有:下鼻甲发育不全、鼻咽狭窄和鼻咽蹼。
平均随访时间为6年,范围为1至14年。94%的儿童后鼻孔功能通畅,6%出现严重再狭窄,直径小于4毫米,均需再次手术。收费患者的预后并不更差。未出现鼻外瓣膜狭窄和永久性咽鼓管功能障碍。3例下鼻甲增生患者出现粘连。无患者出现鼻生长不协调。在孤立性双侧CCA的新生儿中,术后1天(范围1 - 2天)即可开始吸乳,平均需要使用止痛药1.5天(范围1 - 4天)。单侧孤立性CCA的平均住院时间为1.5天(范围1 - 2天),双侧孤立性CCA为8天(范围3 - 2天)。12例患者需要在短时间全身麻醉下进行术后操作,其中10例为6个月以下的婴儿。
即使是单侧闭锁,在新生儿生命早期也可安全进行手术。通过以下方法可将再狭窄倾向降至最低:1. 通过切除犁骨后部和磨除翼突内侧板构建尽可能大的单侧新后鼻孔;2. 对于鼻咽狭窄,应切除部分斜坡软骨内骨;3. 所有创面均应用多个黏膜瓣覆盖并用纤维蛋白胶固定;4. 不进行支架置入;5. 进行适当的术后护理。