Delsart Pascal, Ledieu Guillaume Jean, Ramdane Nassima, Sobocinski Jonathan Paul, Clough Rachel Elizabeth, Azzaoui Richard Oussama, Mounier-Vehier Claire, Nienaber Christoph Anton, Haulon Stephan
Centre Hospitalier Universitaire de Lille, Cardiology hospital, Lille, France.
Centre Hospitalier Universitaire de Lille, Cardiology hospital, Lille, France.
Am J Cardiol. 2017 Aug 1;120(3):484-488. doi: 10.1016/j.amjcard.2017.04.052. Epub 2017 May 11.
Ambulatory blood pressure (BP) measurement (ABPM) is recommended to assess optimal BP control, and we studied its influence after an acute type B aortic dissection (ATBAD). We retrospectively collected data from 111 patients with ATBAD from January 2004 to September 2014. Controlled BP group was defined according to a 24-hour BP under 130/80 mm Hg during chronic phase. The population consisted of 85 men, with a mean age of 61 ± 13 years and mean body mass index of 28 ± 6 kg/m. The median delay between ambulatory BP measurement and ATBAD was 2 (0.3 to 4) months. The mean 24-hour BP of the entire population was 124/71 ± 15/8.8 mm Hg. BP was not controlled in 41 patients (37%). The treatment score at discharge was 3.9 ± 1.4. The mean glomerular filtration rate was 83 ± 28 ml/min/1.73 m, with no difference between groups. Visceral stent implantation in the acute phase (odds ratio [OR] 3.857 [1.199 to 12.406], p = 0.023), higher left ventricular ejection fraction (OR 1.092 [1.005 to 1.187], p = 0.038), and higher platelet count at discharge (OR 1.064 [1.018 to 1.112], p = 0.006) were identified as predictors of good BP control by multivariate analysis. The analysis showed that nighttime systolic BP was associated with aortic events during follow-up (hazard ratio [HR] 5.2 [1.01 to 27.2], p = 0.049), particularly for a threshold of 124 mm Hg or more (HR 1.967 [1.052 to 3.678], p = 0.0341). Nighttime pulse pressure showed also its significance (HR 20.1 [1.4 to 282.7], p = 0.026). In conclusion, subclinical renal malperfusion revascularization seems to improve BP control. A greater nighttime systolic BP was associated with the risk of new aortic events during follow-up.
推荐采用动态血压监测(ABPM)来评估血压的最佳控制情况,我们研究了其在急性B型主动脉夹层(ATBAD)后的影响。我们回顾性收集了2004年1月至2014年9月期间111例ATBAD患者的数据。根据慢性期24小时血压低于130/80 mmHg来定义血压控制组。研究人群包括85名男性,平均年龄为61±13岁,平均体重指数为28±6 kg/m²。动态血压监测与ATBAD之间的中位间隔时间为2(0.3至4)个月。整个人群的平均24小时血压为124/71±15/8.8 mmHg。41例患者(37%)血压未得到控制。出院时的治疗评分为3.9±1.4。平均肾小球滤过率为83±28 ml/min/1.73 m²,各组之间无差异。多因素分析确定急性期内脏支架植入(比值比[OR] 3.857 [1.199至12.406],p = 0.023)、较高的左心室射血分数(OR 1.092 [1.005至1.187],p = 0.038)以及出院时较高的血小板计数(OR 1.064 [1.018至1.112],p = 0.006)是血压良好控制的预测因素。分析表明,夜间收缩压与随访期间的主动脉事件相关(风险比[HR] 5.2 [1.01至27.2],p = 0.049),特别是对于阈值为124 mmHg或更高的情况(HR 1.967 [1.052至3.678],p = 0.0341)。夜间脉压也显示出其重要性(HR 20.1 [1.4至282.7],p = 0.026)。总之,亚临床肾灌注不良的血运重建似乎可改善血压控制。较高的夜间收缩压与随访期间新的主动脉事件风险相关。