Petraitis Vidmantas, Petraitiene Ruta, Hope William W, Walsh Thomas J
Transplantation-Oncology Infectious Diseases Program, Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine of Cornell University, New York, NY, USA.
Antimicrobial Pharmacodynamics and Therapeutics, Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK.
Methods Mol Biol. 2017;1625:259-277. doi: 10.1007/978-1-4939-7104-6_18.
Multiple animal models have been developed to study the pathogenesis of invasive pulmonary aspergillosis, as well as to evaluate the efficacy, pharmacokinetics, and pharmacodynamics of various antifungal agents and vaccines. Each model is beneficial depending on the questions that are asked. In this chapter, we will discuss the endpoints assessment of the persistently neutropenic rabbit models of invasive pulmonary aspergillosis and invasive pulmonary mucormycosis.
已经开发了多种动物模型来研究侵袭性肺曲霉病的发病机制，以及评估各种抗真菌药物和疫苗的疗效、药代动力学和药效学。每种模型根据所提出的问题都有其益处。在本章中，我们将讨论侵袭性肺曲霉病和侵袭性肺毛霉病持续中性粒细胞减少兔模型的终点评估。
