Telethon Kids Institute, Perth, WA, Australia.
Department of Endocrinology and Diabetes, Princess Margaret Hospital for Children, Perth, WA, Australia.
Diabet Med. 2017 Oct;34(10):1440-1446. doi: 10.1111/dme.13396. Epub 2017 Jul 12.
To investigate whether a 10-second (s) sprint impairs the counter-regulatory response to subsequent hypoglycaemia.
Nine people (five male, four female) with Type 1 diabetes, aged 21.1 ± 4.5 years, performed a 10-s rest or a 10-s maximum-effort sprint in random order on different days, while subjected to an euinsulinaemic-euglycaemic clamp. This was followed by a hyperinsulinaemic-hypoglycaemic glucose clamp 2.5 h later to induce hypoglycaemia for 40 min. At timed intervals, the counter-regulatory hormonal responses to hypoglycaemia were measured. Blood pressure, heart rate and hypoglycaemic symptoms were also assessed.
During the hypoglycaemic clamp, epinephrine, norepinephrine, growth hormone and cortisol levels increased significantly from baseline, and their responses were similar after both rest and sprint conditions. In particular, plasma epinephrine rose eightfold, from 197 ± 103 pmol/l to 1582 ± 1118 pmol/l after the rest condition, and from 219 ± 119 pmol/l to 1900 ± 898 pmol/l after the sprint condition.
A 10-s sprint is unlikely to blunt the subsequent hormonal counter-regulation to hypoglycaemia in individuals with Type 1 diabetes.
研究 10 秒冲刺是否会损害随后低血糖的代偿反应。
9 名 1 型糖尿病患者（5 男 4 女），年龄 21.1 ± 4.5 岁，在不同天随机进行 10 秒休息或 10 秒最大努力冲刺，同时进行胰岛素-血糖钳夹。2.5 小时后进行高胰岛素-低血糖葡萄糖钳夹，以诱导 40 分钟的低血糖。在定时间隔测量低血糖时的激素代偿反应。还评估了血压、心率和低血糖症状。
在低血糖钳夹期间，肾上腺素、去甲肾上腺素、生长激素和皮质醇水平从基线显著升高，在休息和冲刺条件下的反应相似。特别是，血浆肾上腺素从休息条件下的 197 ± 103 pmol/l 升高至 1582 ± 1118 pmol/l，从冲刺条件下的 219 ± 119 pmol/l 升高至 1900 ± 898 pmol/l。
10 秒冲刺不太可能削弱 1 型糖尿病患者随后对低血糖的激素代偿反应。
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