Suzaki Asaki, Maeda Naoyuki, Fuchihata Mutsumi, Koh Shizuka, Nishida Kohji, Fujikado Takashi
Department of Applied Visual Science, Osaka University Graduate School of Medicine, Suita, Japan 2Clinical Research and Development Center, Menicon Co., Ltd., Nagoya, Japan.
Department of Ophthalmology, Osaka University Graduate School of Medicine, Suita, Japan.
Invest Ophthalmol Vis Sci. 2017 Jun 1;58(7):2899-2905. doi: 10.1167/iovs.16-21296.
To evaluate the visual performance and optical quality of a standardized asymmetric soft contact lens (SCL) used for correction of higher-order aberrations (HOAs) in eyes with keratoconus.
We included 30 eyes (26 patients) with keratoconus (average K: 45.7 ± 2.3 diopters [D]). The patients were subjected to corneal tomography, aberrometry, measurements of manifest refraction and visual acuity (VA), and visual analog scale (VAS) assessments. The study lenses were made using a molding method and consisted of six standardized types, in which an asymmetric power distribution of approximately 2 to 12 D (2-D step) was used to correct HOAs. The lens type suitable for each eye was selected based on the corneal tomography and aberrometry data. The on-eye performance of the lens was evaluated using aberrometry (4-mm pupil), over refraction, VA, and VAS.
The standardized asymmetric SCL improved the best spectacle-corrected VA from -0.07 ± 0.09 to -0.11 ± 0.08 logMAR (P < 0.05) and the mean VAS score from 66.2 ± 21.8 to 75.4 ± 20.5 (P < 0.05). Vertical coma decreased significantly (-0.50 ± 0.36 μm without SCL; -0.36 ± 0.34 μm with SCL; P < 0.01). In subgroup analysis, subjects in the high VAS group (score ≥ 75) accounted for 70% of all subjects, and this was the group in which the vertical coma decreased significantly from the level without the lens.
A standardized asymmetric SCL can reduce HOAs and improve vision quality when compared with spectacles in patients with keratoconus who wear rigid gas-permeable lenses.
评估用于矫正圆锥角膜患者高阶像差(HOA)的标准化非对称软性接触镜(SCL)的视觉性能和光学质量。
我们纳入了30只圆锥角膜眼(26例患者)(平均角膜曲率:45.7±2.3屈光度[D])。对患者进行角膜地形图检查、像差测量、显验光和视力(VA)测量以及视觉模拟量表(VAS)评估。研究用镜片采用模压法制作,包括六种标准化类型,其中使用约2至12 D(2-D步长)的非对称屈光力分布来矫正高阶像差。根据角膜地形图和像差测量数据为每只眼睛选择合适的镜片类型。使用像差测量(4-mm瞳孔)、复验光、视力和视觉模拟量表评估镜片的眼内性能。
标准化非对称软性接触镜将最佳眼镜矫正视力从-0.07±0.09提高到-0.11±0.08 logMAR(P<0.05),平均视觉模拟量表评分从66.2±21.8提高到75.4±20.5(P<0.05)。垂直彗差显著降低(无软性接触镜时为-0.50±0.36μm;有软性接触镜时为-0.36±0.34μm;P<0.01)。在亚组分析中,高视觉模拟量表评分组(评分≥75)占所有受试者的70%,该组垂直彗差从无镜片时的水平显著降低。
与佩戴硬性透气性镜片的圆锥角膜患者使用的眼镜相比,标准化非对称软性接触镜可减少高阶像差并改善视觉质量。