Wang Xiao-Chun, Wang Jian, Tao Hui-Hui, Zhang Chao, Xu Li-Fa
Medical College of Anhui University of Science and Technology, Huainan, China (Department of Pathogen Biology).
Medical College of Anhui University of Science and Technology, Huainan, China (Department of Biochemistry).
Int J Occup Med Environ Health. 2017 Jul 14;30(5):791-802. doi: 10.13075/ijomeh.1896.00930. Epub 2017 Jun 7.
Objectives: Cigarette smoking is the major risk factor of bladder cancer via exposure to chemical carcinogens. Nicotinamide adenine dinucleotide phosphate (NADP+): quinine oxidoreductase 1 (NQO1) and sulfotransferase 1A1 (SULT1A1) have been reported to involve in the metabolism of polycyclic aromatic hydrocarbons (PAHs) and aromatic amines. Therefore, the risk of bladder cancer (BC) may be influenced by polymorphisms in the genes that modulate metabolic detoxification in particular by interacting with cigarette smoking. Considering the limited power by the individual studies with a relatively small sample size, especially when analyzing the combined effect of polymorphisms in NQO1 and SULT1A1 genes and smoking, these 2 meta-analyses have aimed to clarify the combined effects of them on BC risk by integrating related studies.
Two meta-analyses included 1341 cases and 1346 controls concerning NQO1 Pro187Ser and smoking, and 1921 cases and 1882 controls on SULT1A1 Arg213His and smoking were performed. Odds ratios (OR) and 95% confidence intervals (CI) were used for assessing the strength of the association.
The result has demonstrated that smokers with NQO1 Pro/Ser or Ser/Ser genotypes have a prominent association with the risk of BC as compared with non-smokers with NQO1 Pro/Pro genotype, with OR equal to 3.71 (95% CI: 2.87-4.78, p = 0.376). Besides, smokers carrying SULT1A1 Arg/Arg genotypes were observed to confer 2.38 fold increased risk of BC (95% CI: 1.44-3.93, p = 0.001) when compared with non-smokers with SULT1A1 Arg/Arg or His/His genotypes.
These findings have suggested that the NQO1 Pro187Ser or SULT1A1 Arg213His polymorphism combination with smoking significantly confer susceptibility to BC. Int J Occup Med Environ Health 2017;30(5):791-802.
吸烟是膀胱癌的主要危险因素，通过接触化学致癌物导致发病。据报道，烟酰胺腺嘌呤二核苷酸磷酸（NADP+）：奎宁氧化还原酶1（NQO1）和磺基转移酶1A1（SULT1A1）参与多环芳烃（PAHs）和芳香胺的代谢。因此，膀胱癌（BC）的风险可能受到调节代谢解毒基因多态性的影响，尤其是与吸烟相互作用时。考虑到个体研究样本量相对较小，统计效能有限，特别是在分析NQO1和SULT1A1基因多态性与吸烟的联合效应时，这两项荟萃分析旨在通过整合相关研究来阐明它们对BC风险的联合作用。
两项荟萃分析分别纳入了1341例病例和1346例对照，涉及NQO1 Pro187Ser与吸烟的关系；以及1921例病例和1882例对照，涉及SULT1A1 Arg213His与吸烟的关系。采用比值比（OR）和95%置信区间（CI）评估关联强度。
结果表明，与NQO1 Pro/Pro基因型的非吸烟者相比，NQO1 Pro/Ser或Ser/Ser基因型的吸烟者与BC风险显著相关，OR等于3.71（95%CI：2.87 - 4.78，p = 0.37
