Maciel-Barón Luis Ángel, Pérez Viviana I, Torres Carmen, González-Puertos Viridiana Y, Konigsberg Mina, López-Diazguerrero Norma Edith
Departamento de Ciencias de la Salud, Universidad Autónoma Metropolitana Iztapalapa, Ciudad de México, México.
Rev Med Inst Mex Seguro Soc. 2017 Jul-Aug;55(4):490-497.
Cellular senescence has been traditionally characterized by cell cycle arrest of pot-mitotic cells as a response to a cellular damage. Now is known that senescent cells secret a diverse array of cytokines, chemokines, growth factors and other that altogether are called senescence associates secretory phenotype (SASP), which might have beneficial or deleterious effects on neighbor cells. This review describes those effects as well as the relationship between the SASP and several age related diseases. We also analyze the direction that recent investigations are turning in order to modulate or avoid the effect of the SASP in those pathologies.
传统上，细胞衰老的特征是有丝分裂后细胞的细胞周期停滞，作为对细胞损伤的一种反应。现在已知衰老细胞会分泌多种细胞因子、趋化因子、生长因子等，这些统称为衰老相关分泌表型（SASP），其可能对邻近细胞产生有益或有害的影响。本综述描述了这些影响以及SASP与几种年龄相关疾病之间的关系。我们还分析了近期研究为调节或避免SASP在这些病理状况中的作用而转向的方向。
