RBR 泛素转移：并非简单的“开”与“关”？
RBR Ubiquitin Transfer: Not Simply an "Open" and "Closed" Case?
机构信息
Department of Biochemistry, The University of Western Ontario, London, ON N6A 5C1, Canada.
Department of Biochemistry, The University of Western Ontario, London, ON N6A 5C1, Canada.
出版信息
Structure. 2017 Jun 6;25(6):817-819. doi: 10.1016/j.str.2017.05.013.
PMID:28591621
Abstract
The three distinct types of E3 ubiquitin ligases, RING, HECT, and RBR, employ different modes of ubiquitin transfer including E2∼Ub conjugate type and conformation. In this issue of Structure, Dove et al. (2017) provide a structural rationale for the preference and conformation of the UbcH7∼Ub conjugate by the RBR E3 ligase HHARI.
摘要
三种不同类型的 E3 泛素连接酶，RING、HECT 和 RBR，采用不同的泛素转移模式，包括 E2∼Ub 缀合物类型和构象。在本期《结构》杂志中，Dove 等人（2017）为 RBR E3 连接酶 HHARI 对 UbcH7∼Ub 缀合物的偏好和构象提供了结构依据。
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