Zhonghua Nei Ke Za Zhi. 2017 Jun 1;56(6):453-459. doi: 10.3760/cma.j.issn.0578-1426.2017.06.015.
Invasive fungal disease(IFD) is a common yet highly lethal complication in patients with hematological malignancies receiving chemotherapy or stem cell transplantation, as well as immune suppressive conditions including aplastic anemia and other malignancies. According to the diagnostic criteria, patients are defined as proven, probable, possible and undefined IFD based on the evidence provided by histopathologic/cytologic, culture, radiographic and biomarker examinations. For the management of IFD, the major treatment strategies consist of prophylaxis, empirical, diagnostic-driven and target therapy. The Chinese Invasive Fungal Infection Working Group has developed the Chinese consensus for the diagnosis and treatment of invasive fungal disease based on international guidelines and local experience. Recently, the working group revises the consensus by update international guidelines and clinical studies in China.
侵袭性真菌病(IFD)是接受化疗或干细胞移植的血液系统恶性肿瘤患者以及包括再生障碍性贫血和其他恶性肿瘤在内的免疫抑制状态患者中常见但致死率很高的并发症。根据诊断标准,基于组织病理学/细胞学、培养、影像学和生物标志物检查所提供的证据,患者被定义为确诊、很可能、可能和未确定的IFD。对于IFD的管理,主要治疗策略包括预防、经验性、诊断驱动和靶向治疗。中国侵袭性真菌感染工作组已根据国际指南和本地经验制定了中国侵袭性真菌病诊断和治疗的共识。最近,该工作组通过更新国际指南和中国的临床研究对该共识进行了修订。