癌症类型的有机阴离子转运多肽1B3（OATP1B3）信使核糖核酸（mRNA）有潜力成为人类结直肠癌的检测和预后生物标志物。
Cancer-type OATP1B3 mRNA has the potential to become a detection and prognostic biomarker for human colorectal cancer.
作者信息
Sun Yuchen, Harada Manami, Shimozato Osamu, Souda Hiroaki, Takiguchi Nobuhiro, Nabeya Yoshihiro, Kamijo Takehiko, Akita Hidetaka, Anzai Naohiko, Chiba Kan, Furihata Tomomi
机构信息
Laboratory of Pharmacology & Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan.
Laboratory of DNA Damage Signaling, Chiba Cancer Center Research Institute, Chiba, Japan.
出版信息
Biomark Med. 2017 Aug;11(8):629-639. doi: 10.2217/bmm-2017-0098. Epub 2017 Jun 8.
AIM
We aimed to clarify diagnostic and prognostic biomarker potentials of cancer-type organic anion transporting polypeptide 1B3 (Ct-OATP1B3) mRNA in colorectal cancer (CRC) patients.
PATIENTS & METHODS: Ct-OATP1B3 mRNA levels in 97 CRC and adjacent normal colon tissues were measured by real-time PCR. The receiver operating characteristic curve analysis and the Kaplan-Meier curve analysis were performed to characterize its biomarker potentials.
RESULTS
Ct-OATP1B3 mRNA showed noticeable diagnostic power (the area under the receiver operating characteristic = 0.91) in the CRC patients. Additionally, the higher/lower mRNA expression was clearly associated with better/poorer overall survival in the CRC patients (p < 0.05).
CONCLUSION
Ct-OATP1B3 mRNA has the potential to be a tissue-based biomarker for definitive diagnosis and prognostic stratification in CRC.
目的
我们旨在阐明癌症类型有机阴离子转运多肽1B3（Ct-OATP1B3）mRNA在结直肠癌（CRC）患者中的诊断和预后生物标志物潜力。
患者与方法
通过实时PCR测量97例CRC及相邻正常结肠组织中Ct-OATP1B3 mRNA水平。进行受试者工作特征曲线分析和Kaplan-Meier曲线分析以表征其生物标志物潜力。
结果
Ct-OATP1B3 mRNA在CRC患者中显示出显著的诊断能力（受试者工作特征曲线下面积 = 0.91）。此外，较高/较低的mRNA表达与CRC患者较好/较差的总生存期明显相关（p < 0.05）。
结论
Ct-OATP1B3 mRNA有潜力成为CRC中用于明确诊断和预后分层的基于组织的生物标志物。
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