IL6 rs1800796 与老年墨西哥女性髋部骨折相关，但 IL6 rs1800795、IL6R rs4845617 和 rs2228145 多态性与髋部骨折无关。

Association of the IL6 rs1800796, but not of the IL6 rs1800795, IL6R rs4845617 and rs2228145 polymorphisms with hip fracture in elderly Mexican women.

机构信息

Genetics Laboratory, Dirección de Investigación, Instituto Nacional de Rehabilitación, Calzada México-Xochimilco No. 289 Arenal de Guadalupe, 14389, México, D.F., México.

Medicine Faculty, Universidad Nacional Autónoma de México, México, D.F., México.

出版信息

Aging Clin Exp Res. 2018 Apr;30(4):407-410. doi: 10.1007/s40520-017-0779-7. Epub 2017 Jun 7.

DOI:10.1007/s40520-017-0779-7

PMID:28593468

Abstract

BACKGROUND AND AIMS

Polymorphisms in Interleukin-6 (IL6) and its receptor (IL6R) have been associated with bone mineral density. In this work, the G-174C and G-572C polymorphisms in IL6, G-208A, and Asp358Ala in IL6R were analyzed in Mexican women with hip fracture.

METHODS

Postmenopausal Mexican women (60 years or over) with hip fragility fracture (77.97 ± 8 years) and without hip fracture (70.5 ± 7.02 years) were genotyped by real-time PCR.

RESULTS

The rs1800796 GG genotype was associated with low risk of fracture (p = 0.05), while GC genotype was associated with high risk of fracture [p = 0.047, OR 2.3 (95% CI 1.013-5.2)]. The AA genotype of the rs2228145 SNP (IL6R) was significantly different [p = 0.033, OR 1.94 (95% CI 1.01-3.75)], but when data were adjusted by age and body mass index, there were no differences (p = 0.9).

CONCLUSION

Our results suggest that the IL6 rs1800796 SNP is a good marker for hip fracture risk in Mexican women.

摘要

背景与目的

白细胞介素-6（IL-6）及其受体（IL-6R）的多态性与骨密度有关。在这项工作中，分析了墨西哥髋部骨折女性的 IL-6 的 G-174C 和 G-572C 多态性、IL-6R 的 G-208A 和 Asp358Ala 多态性。

方法

对绝经后髋部脆性骨折（60 岁及以上）的墨西哥女性（77.97±8 岁）和无髋部骨折的女性（70.5±7.02 岁）进行实时 PCR 基因分型。

结果

rs1800796 GG 基因型与骨折风险低相关（p=0.05），而 GC 基因型与骨折风险高相关（p=0.047，OR 2.3（95%CI 1.013-5.2））。rs2228145 SNP（IL-6R）的 AA 基因型差异显著（p=0.033，OR 1.94（95%CI 1.01-3.75）），但当数据按年龄和体重指数调整时，无差异（p=0.9）。