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Cervical Evaluation: From Ancient Medicine to Precision Medicine.宫颈评估：从古代医学到精准医学。
Obstet Gynecol. 2017 Jul;130(1):51-63. doi: 10.1097/AOG.0000000000002106.
2
A five century evolution of cervical incompetence as a clinical entity.
Curr Pharm Des. 2005;11(6):687-97. doi: 10.2174/1381612053381909.
3
[Cervix incompetence].
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4
Diagnosis of cervical change in pregnancy by means of transvaginal ultrasonography.
Am J Obstet Gynecol. 1992 Mar;166(3):896-900. doi: 10.1016/0002-9378(92)91358-h.
5
McDonald transvaginal cervical cerclage since 1957: from its roots in Australia into worldwide contemporary practice.
BJOG. 2014 Aug;121(9):1107. doi: 10.1111/1471-0528.12874.
6
[Transvaginal echography. An application in the diagnosis of cervical incompetence].
J Gynecol Obstet Biol Reprod (Paris). 1988;17(5):629-33.
7
[Ultrasonographic diagnosis of cervical incompetence].[宫颈机能不全的超声诊断]
Ginekol Pol. 2004 Jul;75(7):518-21.
8
Role of ultrasound in screening patients at risk for preterm delivery.
Obstet Gynecol Clin North Am. 2004 Mar;31(1):125-39. doi: 10.1016/S0889-8545(03)00120-7.
9
Transvaginal sonography in the diagnosis and management of cervical incompetence.
Gynecol Obstet Invest. 1993;36(1):59-61. doi: 10.1159/000292596.
10
The significance of transvaginal ultrasonographic evaluation of the cervix in women treated with emergency cerclage.经阴道超声评估宫颈在接受紧急宫颈环扎术治疗的女性中的意义。
Am J Obstet Gynecol. 1996 Aug;175(2):471-6. doi: 10.1016/s0002-9378(96)70164-3.

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Role of the Bishop Score in Predicting Successful Induction of Vaginal Delivery: A Systematic Review of Current Evidence.Bishop评分在预测阴道分娩引产成功中的作用：当前证据的系统评价
Cureus. 2025 Jul 7;17(7):e87467. doi: 10.7759/cureus.87467. eCollection 2025 Jul.
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First-Order Speckle Statistics for the Detection of Microstructural Anisotropy.用于检测微观结构各向异性的一阶散斑统计
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Predicting Spontaneous Labor beyond 39 Weeks among Low-Risk Expectantly Managed Pregnant Patients.预测低危期待管理的孕妇超过 39 周的自发性分娩。
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Reliability of ultrasound versus digital vaginal examination in detecting cervical dilatation during labor: a diagnostic test accuracy systematic review.超声与指诊检查在分娩期间检测宫颈扩张的可靠性：一项诊断试验准确性的系统评价
Ultrasound J. 2021 Aug 17;13(1):37. doi: 10.1186/s13089-021-00239-1.
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Shear wave dispersion as a potential biomarker for cervical remodeling during pregnancy: evidence from a non-human primate model.剪切波频散作为孕期宫颈重塑的潜在生物标志物：来自非人类灵长类动物模型的证据。
Front Phys. 2021 Feb;8. doi: 10.3389/fphy.2020.606664. Epub 2021 Feb 15.
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Aspiration technique-based device is more reliable in cervical stiffness assessment than digital palpation.基于吸引技术的设备在评估颈椎僵硬方面比数字触诊更可靠。
BMC Pregnancy Childbirth. 2020 Jul 6;20(1):391. doi: 10.1186/s12884-020-03080-x.
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Labour and delivery: a clinician's perspective on a biomechanics problem.分娩：临床医生对生物力学问题的看法
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Quantitative Ultrasound Parameters Based on the Backscattered Echo Power Signal as Biomarkers of Cervical Remodeling: A Longitudinal Study in the Pregnant Rhesus Macaque.基于背向散射回波功率信号的定量超声参数作为宫颈重塑生物标志物的研究：恒河猴孕期纵向研究
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Quantitative Ultrasound Biomarkers Based on Backscattered Acoustic Power: Potential for Quantifying Remodeling of the Human Cervix during Pregnancy.基于背向散射声功率的定量超声生物标志物：孕期量化人类宫颈重塑的潜力
Ultrasound Med Biol. 2019 Feb;45(2):429-439. doi: 10.1016/j.ultrasmedbio.2018.08.019. Epub 2018 Nov 22.

本文引用的文献

1
Predictive Accuracy of Serial Transvaginal Cervical Lengths and Quantitative Vaginal Fetal Fibronectin Levels for Spontaneous Preterm Birth Among Nulliparous Women.初产妇中连续经阴道测量宫颈长度及定量检测阴道胎儿纤维连接蛋白水平对自发性早产的预测准确性
JAMA. 2017 Mar 14;317(10):1047-1056. doi: 10.1001/jama.2017.1373.
2
Assessment of Structural Heterogeneity and Viscosity in the Cervix Using Shear Wave Elasticity Imaging: Initial Results from a Rhesus Macaque Model.使用剪切波弹性成像评估子宫颈的结构异质性和粘度：恒河猴模型的初步结果。
Ultrasound Med Biol. 2017 Apr;43(4):790-803. doi: 10.1016/j.ultrasmedbio.2016.12.006. Epub 2017 Feb 8.
3
Committee Opinion No. 687: Approaches to Limit Intervention During Labor and Birth.委员会意见 No.687：限制分娩过程干预的方法。
Obstet Gynecol. 2017 Feb;129(2):e20-e28. doi: 10.1097/AOG.0000000000001905.
4
Precision targeted therapy of ovarian cancer.卵巢癌的精准靶向治疗
J Control Release. 2016 Dec 10;243:250-268. doi: 10.1016/j.jconrel.2016.10.014. Epub 2016 Oct 14.
5
Biomarkers of spontaneous preterm birth: a systematic review of studies using multiplex analysis.自发性早产的生物标志物：对使用多重分析的研究的系统评价
J Perinat Med. 2017 Jan 1;45(1):71-84. doi: 10.1515/jpm-2016-0097.
6
Tissue elastography imaging of the uterine cervix during pregnancy.孕期子宫颈的组织弹性成像
J Med Ultrason (2001). 2007 Dec;34(4):209-10. doi: 10.1007/s10396-007-0150-2. Epub 2007 Dec 14.
7
Cervical elastography during pregnancy: a critical review of current approaches with a focus on controversies and limitations.孕期宫颈弹性成像：对当前方法的批判性综述，重点关注争议和局限性。
J Med Ultrason (2001). 2016 Oct;43(4):493-504. doi: 10.1007/s10396-016-0723-z. Epub 2016 Jun 3.
8
A new paradigm for the role of smooth muscle cells in the human cervix.人类子宫颈中平滑肌细胞作用的新范式。
Am J Obstet Gynecol. 2016 Oct;215(4):478.e1-478.e11. doi: 10.1016/j.ajog.2016.04.053. Epub 2016 May 7.
9
Fetal fibronectin testing for prevention of preterm birth in singleton pregnancies with threatened preterm labor: a systematic review and metaanalysis of randomized controlled trials.胎儿纤连蛋白检测对有早产风险的单胎妊娠预防早产的作用：随机对照试验的系统评价和荟萃分析
Am J Obstet Gynecol. 2016 Oct;215(4):431-8. doi: 10.1016/j.ajog.2016.04.038. Epub 2016 Apr 29.
10
The role of routine cervical length screening in selected high- and low-risk women for preterm birth prevention.常规宫颈长度筛查在选定的高危和低危早产预防女性中的作用。
Am J Obstet Gynecol. 2016 Sep;215(3):B2-7. doi: 10.1016/j.ajog.2016.04.027. Epub 2016 Apr 28.

宫颈评估：从古代医学到精准医学。

Cervical Evaluation: From Ancient Medicine to Precision Medicine.

作者信息

Feltovich Helen

机构信息

Department of Maternal-Fetal Medicine, Intermountain Healthcare, Utah Valley Hospital, Provo, Utah; and the Department of Medical Physics, University of Wisconsin-Madison, Madison, Wisconsin.

出版信息

Obstet Gynecol. 2017 Jul;130(1):51-63. doi: 10.1097/AOG.0000000000002106.

DOI:10.1097/AOG.0000000000002106
PMID:28594774
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5503468/
Abstract

Since ancient times, cervical assessment for predicting timing of delivery has relied primarily on digital (subjective) assessment of dilatation, softening, and length. To date, transvaginal ultrasound cervical length is the only one of these parameters that meets criteria for a biomarker; no objective, quantitative measure of cervical dilatation or softening has gained clinical acceptance. This review discusses how the cervix has been assessed from ancient times to the present day and how a precision medicine approach could improve understanding of not only the cervix, but also parturition in general.

摘要

自古以来，用于预测分娩时间的宫颈评估主要依赖于对宫颈扩张、软化和长度的指诊（主观）评估。迄今为止，经阴道超声测量的宫颈长度是这些参数中唯一符合生物标志物标准的；目前尚无客观、定量的宫颈扩张或软化测量方法获得临床认可。本文综述了从古至今宫颈评估的方式，以及精准医学方法如何不仅能增进对宫颈的理解，还能提升对分娩整体过程的认识。