用于乳腺癌基因治疗的非病毒递送系统
Non-viral Delivery Systems for Breast Cancer Gene Therapy.
作者信息
Vaseghi Golnaz, Rafiee Laleh, Javanmard Shaghayegh Haghjooy
机构信息
Isfahan Cardiovascular Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medicine Sciences, Isfahan. Iran.
Applied Physiology Research Center, Department of Physiology, Isfahan University of Medical Sciences, Isfahan. Iran.
出版信息
Curr Gene Ther. 2017;17(2):147-153. doi: 10.2174/1566523217666170606124131.
INTRODUCTION
The ever-evolving field of gene therapy promises several innovative treatments for cancer. Advances in genetic modification of tumor cells and micro environment have led to the development of more effective therapeutic strategies with fewer side effects.
MATERIALS & METHODS: The development of effective delivery system challenges, remains. Non-viral vectors are interesting due to their bio-safety and their ability to transfer different types of nucleic acids. Examples of these techniques are the use of oligonucleoides, liposomes, nanoparticles, inorganic material, and engineered stem cells.
CONCLUSION
In this review, we focus on recent advances in the intracellular delivery of DNA and siRNA to the cancer cells with emphasis on breast cancer.
引言
基因治疗领域不断发展，有望为癌症带来多种创新疗法。肿瘤细胞和微环境基因改造方面的进展已促成副作用更少的更有效治疗策略的开发。
材料与方法
有效的递送系统仍面临开发方面的挑战。非病毒载体因其生物安全性及其转移不同类型核酸的能力而备受关注。这些技术的实例包括使用寡核苷酸、脂质体、纳米颗粒、无机材料和工程干细胞。
结论
在本综述中，我们重点关注DNA和小干扰RNA（siRNA）向癌细胞内递送的最新进展，重点是乳腺癌。
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