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[室性快速心律失常患者缺血与血运重建的诊断]

[Diagnosis of ischemia and revascularization in patients with ventricular tachyarrhythmia].

作者信息

Deneke Thomas, Israel Carsten W

机构信息

Herz- und Gefäßklinik, Klinik für Interventionelle Elektrophysiologie, Salzburger Leite 1, 97616, Bad Neustadt an der Saale, Deutschland.

Klinik für Innere Medizin - Kardiologie, Diabetologie & Nephrologie, Evangelisches Klinikum Bethel, Bielefeld, Deutschland.

出版信息

Herzschrittmacherther Elektrophysiol. 2017 Jun;28(2):157-161. doi: 10.1007/s00399-017-0515-1. Epub 2017 Jun 8.

Abstract

Sustained ventricular tachyarrhythmia usually occurs on the basis of structural heart disease, particularly coronary heart disease (CAD). Although monomorphic ventricular tachycardia (VT) appears mainly in patients with CAD, it is typically not triggered by acute ischemia, in contrast to polymorphic VT or ventricular fibrillation (VF). To judge if VT is caused by acute ischemia is even more difficult in context with an elevated highly sensitive troponin T which is generally elevated in sustained VT because tachycardia in chronic stable coronary artery sclerosis causes a mismatch between increased oxygen demand and limited oxygen supply. Therefore, acute coronary angiography and revascularization may frequently not be necessary in monomorphic VT, will usually not improve rhythm stabilization, and may lead to misinterpretation of monomorphic VT being caused by a coronary stenosis. This can lead to withholding antiarrhythmic therapy after revascularization since it is assumed that the cause of VT has been treated. On the other hand, acute coronary angiography and revascularization are useful in polymorphic VT/VF, ECG signs of ischemia, or typical chest pain before occurrence of VT/VF. Coronary angiography should also be performed in patients with VT with newly diagnosed reduced left ventricular function and before catheter ablation.

摘要

持续性室性快速心律失常通常发生在结构性心脏病的基础上,尤其是冠心病(CAD)。虽然单形性室性心动过速(VT)主要出现在冠心病患者中,但与多形性VT或室颤(VF)不同,它通常不是由急性缺血触发的。在高敏肌钙蛋白T升高的情况下,判断VT是否由急性缺血引起更加困难,因为在慢性稳定冠状动脉硬化中,心动过速会导致氧需求增加与氧供应受限之间的不匹配,而持续性VT中高敏肌钙蛋白T通常会升高。因此,在单形性VT中,急性冠状动脉造影和血运重建通常可能不必要,通常不会改善心律稳定,并且可能导致将单形性VT误解为由冠状动脉狭窄引起。这可能导致血运重建后停用抗心律失常治疗,因为人们认为VT的病因已经得到治疗。另一方面,急性冠状动脉造影和血运重建对多形性VT/VF、缺血性心电图表现或VT/VF发作前的典型胸痛有用。对于新诊断的左心室功能减退的VT患者以及在导管消融术前,也应进行冠状动脉造影。

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