Filippetti Laura, Huttin Olivier, Selton-Suty Christine, Voilliot Damien
a Centre Hospitalier Universitaire de Nancy, Service de Cardiologie, Institut Lorrain du Cœur et des Vaisseaux , Vandœuvre-lès-Nancy , France.
b IADI, INSERM U947, University of Lorraine , Nancy , France.
Acta Cardiol. 2017 Feb;72(1):9-18. doi: 10.1080/00015385.2017.1281546.
Hypereosinophilia may be due to several aetiologies. Cardiac complications are not uncommon, whatever the causes. Clinical presentations of hypereosinophilic cardiac diseases may vary widely from asymptomatic form to fatal necrotic myocarditis or irreversible restrictive cardiomyopathy. As a major cause of morbidity and mortality, diagnosis of cardiac involvement is crucial. Until recently the diagnosis was exclusively based on cardiac biopsy. Nowadays, multimodal cardiac imaging, including echocardiography and cardiac magnetic resonance imaging, is the cornerstone of the diagnosis. Cardiac magnetic resonance imaging has emerged as a very useful tool for the diagnosis allowing precise tissue characterization. It has even been proposed as a surrogate to cardiac biopsy. It should be systematically performed in case of hypereosinophilia. Early and appropriate treatment is crucial to avoid the evolution toward irreversible cardiac lesions. These treatments are symptomatic but should also be adapted to the underlying diseases.
嗜酸性粒细胞增多症可能由多种病因引起。无论病因如何，心脏并发症都并不罕见。嗜酸性粒细胞增多性心脏病的临床表现差异很大，从无症状形式到致命的坏死性心肌炎或不可逆的限制性心肌病。作为发病和死亡的主要原因，心脏受累的诊断至关重要。直到最近，诊断还完全基于心脏活检。如今，包括超声心动图和心脏磁共振成像在内的多模态心脏成像已成为诊断的基石。心脏磁共振成像已成为一种非常有用的诊断工具，可实现精确的组织特征描述。甚至有人提议将其作为心脏活检的替代方法。在嗜酸性粒细胞增多症的情况下应系统地进行该检查。早期且适当的治疗对于避免发展为不可逆的心脏病变至关重要。这些治疗是对症治疗，但也应根据潜在疾病进行调整。
