Jiangsu Key Laboratory of Pesticide Science and Department of Chemistry, College of Sciences, Nanjing Agricultural University , Nanjing 210095, P. R. China.
College of Plant Protection, Nanjing Agricultural University , Nanjing 210095, P. R. China.
J Org Chem. 2017 Jul 7;82(13):6978-6985. doi: 10.1021/acs.joc.7b00813. Epub 2017 Jun 22.
An acetic acid-mediated sulfonylation of allenylphosphine oxides with sodium sulfinates is disclosed. This new methodology involves tandem (Ar)O-C(sp) bond cleavage and C(sp)/C(sp)-SO formation toward divergent synthesis of sulfonyl- and phosphinyl-bifunctionalized 1,3-butadienes or allenes, depending on the substitution at the terminal carbon atoms of allenylphosphine oxides. The reaction mechanism is explained via an acid-accelerated synergistic process.
本文公开了一种通过醋酸介导的烯丙基膦氧化物与亚磺酸钠的磺酰化反应。这种新方法涉及串联的（Ar）O-C（sp）键断裂和 C(sp)/C(sp)-SO 形成，可根据烯丙基膦氧化物末端碳原子的取代情况，实现磺酰基和膦基双官能化 1,3-丁二烯或烯丙基化合物的发散合成。反应机理通过酸加速协同过程得到解释。
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