低剂量 CT 灌注成像在胃癌中的可行性研究。

The feasibility of low-dose CT perfusion imaging in gastric cancer.

机构信息

Department of Radiology, Affiliated Hospital of Jiangnan University, The Forth People's Hospital of Wuxi City, Wuxi, Jiangsu, China.

Department of Intervention, Affiliated Hospital of Jiangnan University, The Forth People's Hospital of Wuxi City, Wuxi, Jiangsu, China.

出版信息

J Xray Sci Technol. 2017;25(5):847-855. doi: 10.3233/XST-17282.

DOI:10.3233/XST-17282

PMID:28598862

Abstract

PURPOSE

To investigate feasibility of applying low-dose CT perfusion imaging (CTPI) to diagnose gastric cancer.

MATERIALS AND METHODS

Twenty patients with gastric cancer confirmed by endoscopic biopsy were undergone routine dose (120 kV, 100 mA) and low-dose (120 kV, 50 mA) CTPI examination, respectively. The original data were processed by body perfusion software, and the perfusion parameters values including blood flow (BF), blood volume (BV) and permeability surface (PS) of gastric cancer were measured. Statistical data analyses including paired-samples t test, Pearson correlation analysis and Bland-Altman consistency test were used to compare the perfusion parameters values between the routine dose and low-dose CTPI examinations. Radiation dosage, which the patients received during two CTPI examinations, was also calculated and compared.

RESULTS

There were no statistical differences in the BF, BV and PS values between routine dose group and low-dose group (P > 0.05), and there were significant correlation in the BF, BV and PS values between two groups (P < 0.01). The consistency of BF and BV values between the two groups was preferable to that of PS value. The radiation dosage of the low-dose group was much less than that of routine dose group, and the CTDIvol and DLP values of low-dose CTPI were decreased by 50%, respectively.

CONCLUSION

The parameters BF and BV values may play a valuable role in the diagnosis and assessment of gastric cancer in low-dose CTPI examination.

摘要

目的

探讨低剂量 CT 灌注成像（CTPI）在胃癌诊断中的应用可行性。

材料与方法

对 20 例经内镜活检证实为胃癌的患者分别行常规剂量（120kV，100mA）和低剂量（120kV，50mA）CTPI 检查。应用体部灌注软件对原始数据进行处理，测量胃癌的血流（BF）、血容量（BV）和通透性表面（PS）等灌注参数值。采用配对样本 t 检验、Pearson 相关分析和 Bland-Altman 一致性检验对常规剂量和低剂量 CTPI 检查的灌注参数值进行比较。同时计算并比较两种 CTPI 检查中患者所接受的辐射剂量。

结果

常规剂量组与低剂量组 BF、BV 和 PS 值之间差异均无统计学意义（P＞0.05），两组 BF、BV 和 PS 值之间均具有显著相关性（P＜0.01）。两组 BF 和 BV 值的一致性优于 PS 值。低剂量组的辐射剂量明显低于常规剂量组，低剂量 CTPI 的 CTDIvol 和 DLP 值分别降低了 50%。