职业与阻塞性睡眠呼吸暂停：一项荟萃分析

Occupation and Obstructive Sleep Apnea: A Meta-Analysis.

作者信息

Schwartz Daniel A, Vinnikov Denis, Blanc Paul D

机构信息

UC Berkeley-UCSF Joint Medical Program, School of Public Health, University of California, Berkeley, Berkeley (Mr Schwartz); Department of Internal Medicine, Occupational Disease and Hematology, Kyrgyz State Medical Academy, Bishkek, Kyrgyzstan, and School of Public Health, Al-Farabi Kazakh National University, Almaty, Kazakhstan (Dr Vinnikov); Division of Occupational and Environmental Medicine, Department of Medicine, University of California San Francisco, San Francisco (Dr Blanc), California.

出版信息

J Occup Environ Med. 2017 Jun;59(6):502-508. doi: 10.1097/JOM.0000000000001008.

DOI:10.1097/JOM.0000000000001008

PMID:28598928

Abstract

OBJECTIVE

Obstructive sleep apnea (OSA) remains a prevalent condition, but its occupational burden is unclear. We carried out a systematic review to characterize the consistency and magnitude of occupational associations with OSA.

METHODS

We studied OSA within three occupational categories: commercial drivers, organic solvent-exposed workers, other selected occupations. We performed a meta-analysis on the prevalence of OSA among drivers and the risk of OSA associated with solvent exposure.

RESULTS

The pooled OSA prevalence in drivers was 41% (95% confidence interval [CI] 26% to 56%) for apnea hypopnea-index (AHI) is greater than 5, and 15% (95% CI 12% to 19%) for AHI is greater than 15. Exposure to solvents was associated with increased but non-statistically significant risk of OSA: summary relative risk, 2.38 (95% CI 0.89 to 6.32). Evidence of occupational association was inconsistent for other factors.

CONCLUSIONS

OSA is common among commercial drivers and potentially associated with occupations involving likely solvent exposure.

摘要

目的

阻塞性睡眠呼吸暂停（OSA）仍然是一种普遍存在的病症，但其职业负担尚不清楚。我们进行了一项系统综述，以描述与OSA职业关联的一致性和程度。

方法

我们在三个职业类别中研究OSA：商业司机、有机溶剂接触工人、其他选定职业。我们对司机中OSA的患病率以及与溶剂接触相关的OSA风险进行了荟萃分析。

结果

对于呼吸暂停低通气指数（AHI）大于5的情况，司机中OSA的合并患病率为41%（95%置信区间[CI]26%至56%），对于AHI大于15的情况，患病率为15%（95%CI 12%至19%）。接触溶剂与OSA风险增加相关，但无统计学意义：汇总相对风险为2.38（95%CI 0.89至6.32）。其他因素的职业关联证据不一致。