Wu Wan-Ju, Shih Jin-Chung, Sago Haruhiko, Chen Ming
Department of Obstetrics and Gynecology, Changhua Christian Hospital, Changhua, Taiwan; Department of Genomic Medicine, Center for Medical Genetics, Changhua Christian Hospital, Changhua, Taiwan.
Department of Obstetrics and Gynecology, College of Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Taiwan J Obstet Gynecol. 2017 Jun;56(3):402-405. doi: 10.1016/j.tjog.2017.04.027.
We presented a fetus affected by macrocystic lung lesions with progressive hydropic changes during the second trimester, but experienced remarkable resolution of hydrops in the third trimester after a series of in utero interventions.
A 19-year-old women, G1P0, presented with fetal multilocular thoracic mass and hydropic change at 23 weeks of gestation. After non-directive genetic counseling, she opted for intrauterine cyst aspiration followed by intra-cystic OK-432 injection at 24 weeks of pregnancy, as well as sequential thoracoamniotic shunts at 26 weeks and 27 weeks of pregnancy when we observed hydrops developed progressively. Finally, the hydrops resolved in the third trimester and a healthy baby was born at 33 weeks of pregnancy, in which further surgical intervention was performed at five-month old.
Thoracoamniotic shunting is a preferred option for all hydropic fetuses resulted from large macrocystic lung lesions to enhance perinatal survival rate.
我们报告了一例在孕中期受大囊性腺瘤样肺囊肿病变影响且出现进行性水肿改变的胎儿,但在孕晚期经过一系列宫内干预后水肿显著消退。
一名19岁女性,孕1产0,在妊娠23周时出现胎儿多房性胸部肿块及水肿改变。经过非指导性遗传咨询后,她选择在妊娠24周时进行宫内囊肿抽吸,随后囊内注射OK-432,并且在妊娠26周和27周时,当观察到水肿进行性发展时,相继进行胸腔羊膜分流术。最终,水肿在孕晚期消退,妊娠33周时娩出一名健康婴儿,该婴儿在5个月大时接受了进一步的手术干预。
胸腔羊膜分流术是所有因大囊性腺瘤样肺囊肿病变导致水肿的胎儿提高围生期存活率的首选方法。