早期抗逆转录病毒疗法可降低围产期HIV感染后的HIV DNA水平。
Early antiretroviral therapy reduces HIV DNA following perinatal HIV infection.
作者信息
Foster Caroline, Pace Matthew, Kaye Steve, Hopkins Emily, Jones Mathew, Robinson Nicola, Mant Christine, Cason John, Fidler Sarah, Frater John
机构信息
aDivision of Medicine, Wright Fleming Institute, Imperial College, London bNuffield Department of Clinical Medicine, John Radcliffe Hospital, Peter Medawar Building for Pathogen Research, Oxford cKing's College London Infectious Diseases BioBank, London dInstitute for Emerging Infections, The Oxford Martin School eOxford National Institute of Health Research Biomedical Research Centre, Oxford, UK. *Caroline Foster, Sarah Fidler, and John Frater contributed equally to this article.
出版信息
AIDS. 2017 Aug 24;31(13):1847-1851. doi: 10.1097/QAD.0000000000001565.
: The impact of antiretroviral therapy (ART) on the size of the HIV reservoir has implications for virological remission in adults, but is not well characterized in perinatally acquired infection. In a prospective observational study of 20 children with perinatally acquired infection and sustained viral suppression on ART for more than 5 years, proviral DNA was significantly higher in deferred (>4 years) versus early (first year of life) ART recipients (P = 0.0062), and correlated with age of initiation (P = 0.13; r = 0.57). No difference was seen in cell-associated viral RNA (P = 0.36). Identifying paediatric populations with smaller reservoirs may inform strategies with potential to induce ART-free remission.
抗逆转录病毒疗法（ART）对HIV储存库大小的影响关乎成人的病毒学缓解，但在围产期获得性感染中的特征尚不明确。在一项针对20名围产期获得性感染儿童的前瞻性观察研究中，这些儿童接受ART治疗超过5年且病毒持续受到抑制，延迟（>4年）接受ART治疗的儿童与早期（生命第一年）接受ART治疗的儿童相比，前病毒DNA显著更高（P = 0.0062），且与开始治疗的年龄相关（P = 0.13；r = 0.57）。细胞相关病毒RNA未见差异（P = 0.36）。识别储存库较小的儿科人群可能为诱导无ART缓解的潜在策略提供依据。
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