Saxena A K, Saksena A K, Agnihotri M S, Vrat S, Tangri K K, Bhargava K P
Naunyn Schmiedebergs Arch Pharmacol. 1985 Apr;329(2):141-5. doi: 10.1007/BF00501203.
The effect of monoaminergic agonists and antagonists microinjected into mesencephalic nucleus dorsalis raphe has been studied on blood pressure and heart rate to elucidate the nature and role of these monoaminergic receptors in cardiovascular regulation. Microinjection of monoamines, noradrenaline, phenylephrine and 5-hydroxytryptamine (5-HT) into nucleus dorsalis raphe elicited hypertension and tachycardia which could be blocked by local pretreatment with piperoxan (an alpha-adrenoceptor blocker) and methysergide (a 5-HT receptor blocker) respectively. However, isoprenaline microinjections failed to evoke any response. Bilateral vagotomy did not prevent these cardiovascular responses evoked by monoamines microinjection, while cervical spinal cord (C1) transection with bilateral vagotomy prevented these responses. These monoaminergic receptors seem to be localized in nucleus dorsalis raphe since microinjection of monoamines into neural structures adjoining nucleus dorsalis raphe, failed to induce any cardiovascular response. Monoaminergic receptors are present in nucleus dorsalis raphe which modulate cardiovascular activity by influencing sympathetic preganglionic neurons in the intermediolateral columns of the spinal cord.
已对微量注射到中脑背侧缝核中的单胺能激动剂和拮抗剂对血压和心率的影响进行了研究，以阐明这些单胺能受体在心血管调节中的性质和作用。向背侧缝核微量注射单胺、去甲肾上腺素、苯肾上腺素和5-羟色胺（5-HT）可引发高血压和心动过速，分别用哌罗克生（一种α-肾上腺素能受体阻滞剂）和麦角酰二乙胺（一种5-HT受体阻滞剂）进行局部预处理可阻断这些反应。然而，微量注射异丙肾上腺素未能引发任何反应。双侧迷走神经切断术并不能阻止微量注射单胺引发的这些心血管反应，而双侧迷走神经切断术加颈脊髓（C1）横断术则可阻止这些反应。这些单胺能受体似乎定位于背侧缝核，因为向毗邻背侧缝核的神经结构微量注射单胺未能诱导任何心血管反应。背侧缝核中存在单胺能受体，其通过影响脊髓中间外侧柱中的交感神经节前神经元来调节心血管活动。
