Department of Medical Microbiology, Faculty of Medicine, Çukurova University, Adana, Turkey.
Liver and Gastrointestinal Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Turk J Med Sci. 2017 Jun 12;47(3):916-922. doi: 10.3906/sag-1606-116.
BACKGROUND/AIM: is a pathogen that colonizes a majority of the world's population. Genetic diversity within the virulence genes of bacteria such as PAI and A may have a modified effect on the pathogenic potential of the bacteria. This study aimed to investigate which genes can be suggested as potentially related virulence factors for -associated active chronic gastritis and stomach adenocarcinoma in the northwest of Iran and south of Turkey.
Formalin-fixed, paraffin-embedded stomach biopsy tissue samples were obtained from Iranian and Turkish patients from selected geographical regions. The prevalence of selected PAI genes and A genotypes were studied in -positive samples by using polymerase chain reaction and specific primers.
Out of 320 patients, was detected in 28.43% of patients. We found that the and genes with mean prevalences of 82.41%, 71.42%, and 69.23%, respectively, were dominant in Iranian and Turkish patients.
In the south of Turkey and northwest of Iran the studied genes were homogeneous and there were no significant differences in bacterial genetics. The results of this study indicate that and are dominant genes in people with gastric disorders in our selected geographical regions.
背景/目的：是一种定植于世界大部分人口的病原体。细菌如 PAI 和 A 的毒力基因内的遗传多样性可能对细菌的致病潜能产生修饰作用。本研究旨在探讨哪些基因可被认为是伊朗西北部和土耳其南部与相关的活动性慢性萎缩性胃炎和胃腺癌的潜在相关毒力因子。
从选定地理区域的伊朗和土耳其患者中获取福尔马林固定、石蜡包埋的胃活检组织样本。通过聚合酶链反应和特异性引物，在阳性样本中研究选定的 PAI 基因和 A 基因型的流行情况。
在 320 名患者中，28.43%的患者检测到。我们发现，在伊朗和土耳其患者中，分别具有 82.41%、71.42%和 69.23%平均流行率的 和 基因占优势。
在土耳其南部和伊朗西北部，研究的基因具有同源性，细菌遗传学没有显著差异。本研究结果表明， 和 是我们所选地理区域胃疾病患者中占优势的基因。
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