Miguel-Carrera Jonatan, García-Porrua Carlos, de Toro Santos Francisco Javier, Picallo-Sánchez Jose Antonio
Punto de Atención Continuada Fingoi (Lugo), Estructura Organizativa de Gestión Integrada (EOXI) Lugo, Cervo y Monforte, Servicio Galego de Saúde (SERGAS), Lugo, España.
Sección de Reumatología, Hospital Universitario Lucus Augusti (HULA), Servicio Galego de Saúde (SERGAS), Lugo, España.
Aten Primaria. 2018 Mar;50(3):176-183. doi: 10.1016/j.aprim.2017.03.006. Epub 2017 Jun 17.
To study the prevalence of osteoporosis and fracture probability in patients diagnosed with prostate cancer.
Observational descriptive transversal study. SITE: Study performed from Primary Care of Lugo in collaboration with Rheumatology and Urology Services of our referral hospital.
Patients diagnosed with prostate cancer without bone metastatic disease from January to December 2012.
Epidemiologic, clinical, laboratory and densitometric variables involved in osteoporosis were collected. The likelihood of fracture was estimated by FRAX Tool.
Eighty-three patients met the inclusion criteria. None was excluded. The average age was 67 years. The Body Mass Index was 28.28. Twenty-five patients (30.1%) had previous osteoporotic fractures. Other prevalent risk factors were alcohol (26.5%) and smoking (22.9%). Eighty-two subjects had vitamin D below normal level (98.80%). Femoral Neck densitometry showed that 8.9% had osteoporosis and 54% osteopenia. The average fracture risk in this population, estimated by FRAX, was 2.63% for hip fracture and 5.28% for major fracture. Cut level for FRAX major fracture value without DXA >5% and ≥7.5% proposed by Azagra et al. showed 24 patients (28.92%) and 8 patients (9.64%) respectively.
The prevalence of osteoporosis in this population was very high. The more frequent risk factors associated with osteoporosis were: previous osteoporotic fracture, alcohol consumption, smoking and family history of previous fracture. The probability of fracture using femoral neck FRAX tool was low. Vitamin D deficiency was very common (98.8%).
研究前列腺癌患者骨质疏松症的患病率及骨折概率。
观察性描述性横断面研究。
该研究由卢戈初级保健机构与我们转诊医院的风湿病科和泌尿科合作开展。
2012年1月至12月期间诊断为前列腺癌且无骨转移疾病的患者。
收集与骨质疏松症相关的流行病学、临床、实验室及骨密度变量。采用FRAX工具估算骨折可能性。
83例患者符合纳入标准，无一例被排除。平均年龄为67岁，体重指数为28.28。25例患者（30.1%）曾有骨质疏松性骨折。其他常见危险因素为饮酒（26.5%）和吸烟（22.9%）。82名受试者维生素D水平低于正常范围（98.80%）。股骨颈骨密度测量显示，8.9%的患者患有骨质疏松症，54%的患者患有骨质减少症。通过FRAX估算，该人群髋部骨折的平均风险为2.63%，主要骨折的平均风险为5.28%。阿扎格拉等人提出的无双能X线吸收法（DXA）时FRAX主要骨折值的截断水平>5%和≥7.5%，分别显示有24例患者（28.92%）和8例患者（9.64%）。
该人群中骨质疏松症的患病率非常高。与骨质疏松症相关的较常见危险因素为：既往骨质疏松性骨折、饮酒、吸烟及既往骨折家族史。使用股骨颈FRAX工具估算的骨折概率较低。维生素D缺乏非常普遍（98.8%）。
