Medical Research Council Centre for Neuromuscular Diseases, University College London Institute of Neurology, Queen Square, London, WC1N 3BG, UK.
Foot and ankle unit, Royal National Orthopedic Hospital, Stanmore, UK.
Muscle Nerve. 2018 Feb;57(2):255-259. doi: 10.1002/mus.25724. Epub 2017 Jul 7.
Foot deformities are frequent complications in Charcot-Marie-Tooth disease (CMT) patients, often requiring orthopedic surgery. However, there are no prospective, randomized studies on surgical management, and there is variation in the approaches among centers both within and between countries.
In this study we assessed the frequency of foot deformities and surgery among patients recruited into the Inherited Neuropathies Consortium (INC). We also designed a survey addressed to orthopedic surgeons at INC centers to determine whether surgical approaches to orthopedic complications in CMT are variable.
Foot deformities were reported in 71% of CMT patients; 30% of the patients had surgery. Survey questions were answered by 16 surgeons working in different specialized centers. Most of the respondents were foot and ankle surgeons. There was marked variation in surgical management.
Our findings confirm that the approaches to orthopedic management of CMT are varied. We identify areas that require further research. Muscle Nerve 57: 255-259, 2018.
足畸形是 Charcot-Marie-Tooth 病（CMT）患者常见的并发症，常需行矫形手术。然而，目前尚无前瞻性、随机的手术管理研究，且各国各中心之间的手术方法存在差异。
本研究评估了入组遗传性神经病变联合会（INC）的患者中足畸形和手术的发生率。我们还设计了一份针对 INC 中心矫形外科医生的调查问卷，以确定 CMT 矫形并发症的手术方法是否存在差异。
71%的 CMT 患者报告存在足畸形；30%的患者接受了手术。调查问卷的回答来自于在不同专业中心工作的 16 名矫形外科医生。大多数受访者是足踝外科医生。手术管理存在显著差异。
我们的研究结果证实，CMT 的矫形治疗方法存在差异。我们确定了需要进一步研究的领域。《肌肉神经》57:255-259,2018。
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