Department of Diagnostic and Interventional Radiology and Nuclear Medicine, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.
Section of Pediatric Radiology, Department of Diagnostic and Interventional Radiology and Nuclear Medicine, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.
Eur Radiol. 2017 Dec;27(12):5337-5343. doi: 10.1007/s00330-017-4909-6. Epub 2017 Jun 20.
To compare hepatic 2D shear wave elastography (2D SWE) in children between free-breathing and breath-hold conditions, in terms of measurement agreement and time expenditure.
A cohort of 57 children (12.7±4.3 years) who underwent standardized 2D SWE between May and October 2015 were retrospectively evaluated. Liver elastograms were obtained under free-breathing and breath-hold conditions and time expenditure was measured. Median stiffness, interquartile range (IQR), and IQR/median ratio were calculated based on 12, six, and three elastograms. Results were compared using Pearson correlation coefficient, intraclass correlation coefficient (ICC), Bland-Altman analysis, and Student's t.
Median liver stiffness under free-breathing and breath-hold conditions correlated strongly (7.22±4.5kPa vs. 7.21±4.11kPa; r=0.97, P<0.001). Time to acquire 12 elastograms with free-breathing was lower than that with breath-holding (79.3±32.5sec vs. 143.7±51.8sec, P<0.001). Results for median liver stiffness based of 12, six, and three elastograms demonstrated very high agreement for free-breathing (ICC 0.993) and for breath-hold conditions (ICC 0.994).
Hepatic 2D SWE performed with free-breathing yields results similar to the breath-hold condition. With a substantially lower time requirement, which can be further reduced by lowering the number of elastograms, the free-breathing technique may be suitable for infants and less cooperative children not capable of breath-holding.
• Hepatic 2D SWE performed with free-breathing yields results similar to breath-hold condition. • Benefit of the free-breathing approach is the substantially lower time requirement. • Lowering the number of elastograms can further reduce time expenditure. • Free-breathing 2D SWE is suitable in children with suspected liver disease.
比较儿童在自由呼吸和屏气条件下进行二维剪切波弹性成像（2D SWE）的测量一致性和时间消耗。
回顾性分析 2015 年 5 月至 10 月期间接受标准化 2D SWE 的 57 例儿童（12.7±4.3 岁）。在自由呼吸和屏气条件下获得肝脏弹性图，并测量时间消耗。基于 12、6 和 3 个弹性图计算中位数硬度、四分位距（IQR）和 IQR/中位数比。使用 Pearson 相关系数、组内相关系数（ICC）、Bland-Altman 分析和 Student's t 检验比较结果。
自由呼吸和屏气条件下的肝脏硬度中位数相关性很强（7.22±4.5kPa 与 7.21±4.11kPa；r=0.97，P<0.001）。自由呼吸采集 12 个弹性图的时间低于屏气（79.3±32.5sec 与 143.7±51.8sec，P<0.001）。基于 12、6 和 3 个弹性图的中位数肝脏硬度结果在自由呼吸时具有非常高的一致性（ICC 0.993），在屏气条件下也具有非常高的一致性（ICC 0.994）。
自由呼吸下进行的肝脏 2D SWE 产生的结果与屏气条件相似。由于时间要求大大降低，通过降低弹性图的数量可以进一步减少时间消耗，因此自由呼吸技术可能适用于无法屏气的婴儿和合作性较差的儿童。
自由呼吸下进行的肝脏 2D SWE 产生的结果与屏气条件相似。
自由呼吸方法的优点是时间要求大大降低。
降低弹性图的数量可以进一步减少时间消耗。
自由呼吸 2D SWE 适用于怀疑患有肝脏疾病的儿童。
