[/ rearrangement affects multifocal formation of papillary thyroid carcinoma].

/ gene rearrangement can lead to aberrant activation of tyrosine kinase receptors, which is a common mutation in papillary thyroid carcinoma (PTC). This study focuses on the association of / rearrangements with PTC clinical factors. From January 2011 to December 2013, a total of 114 patients with PTC were enrolled in this study. Clinicopathological parameters, lifestyle, and thyroid hormone levels were collected. / rearrangements were detected by TaqMan PCR and verified by Sanger sequencing.Data were analyzed with SPSS software, including chi-square test, ' exact test, - test, '-test, and Logistic regression. / rearrangements were not found in all paracancerous normal thyroid tissues, and were detected in 23.68% (27/114) of PTC. Further analysis revealed no correlation between / rearrangement and thyroid function, clinicopathologic parameters, and lifestyle in the total PTC group or in the subgroup of patients with concomitant diseases (including Hashimoto's thyroiditis and nodular goiter). But in the subgroup of PTC without concomitant disease, / rearrangement was associated with tumor multifocal (=0.018), and /-positive PTC patients had an increased risk of tumor multifocal (=5.57, 95% 1.39-22.33). It was also found that / rearrangement was associated with an abnormal increase in TSH level of one month after surgery (= 0.037). Nodular goiter and Hashimoto 's thyroiditis may be a confounding factor in PTC. / rearrangement may play an important role in the occurrence of thyroid carcinoma multifocal after exclusion of this confounding factor.