逆流而上：病毒诱导宿主关闭期间的选择性细胞蛋白质合成
Going against the Tide: Selective Cellular Protein Synthesis during Virally Induced Host Shutoff.
作者信息
Cao Shuai, Dhungel Pragyesh, Yang Zhilong
机构信息
Division of Biology, Kansas State University, Manhattan, Kansas, USA.
Division of Biology, Kansas State University, Manhattan, Kansas, USA
出版信息
J Virol. 2017 Aug 10;91(17). doi: 10.1128/JVI.00071-17. Print 2017 Sep 1.
Abstract
Many viral infections cause host shutoff, a state in which host protein synthesis is globally inhibited. Emerging evidence from vaccinia and influenza A virus infections indicates that subsets of cellular proteins are resistant to host shutoff and continue to be synthesized. Remarkably, the proteins of oxidative phosphorylation, the cellular-energy-generating machinery, are selectively synthesized in both cases. Identifying mechanisms that drive selective protein synthesis should facilitate understanding both viral replication and fundamental cell biology.
摘要
许多病毒感染会导致宿主关闭，即宿主蛋白质合成受到全面抑制的一种状态。来自痘苗病毒和甲型流感病毒感染的新证据表明，细胞蛋白质的某些亚群对宿主关闭具有抗性，并继续进行合成。值得注意的是，在这两种情况下，氧化磷酸化的蛋白质（即细胞能量产生机制）都会被选择性地合成。确定驱动选择性蛋白质合成的机制应有助于理解病毒复制和基础细胞生物学。
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