Pharmacokinetics of 3-[bis(2-hydroxyethyl)amino]acetophenone-(4,5-diphenyloxazol-2-yl) hydrazone (ZIMET 98/69) after oral administration to mice.

The pharmacokinetics of the hetarylhydrazone derivative 3H-ZIMET 98/69 after oral administration to mice were studied. The absorption of the drug is incomplete and dose-dependent; elimination proceeds slowly, the serum half-life being of about 30 h. Repeated daily administration of the drug leads to a moderate accumulation of radioactivity in serum as well as in various tissues. The moderate bioavailability after oral administration of ZIMET 98/69 has to be considered as one reason for the high doses necessary for the antiviral action of the drug in vivo.