Dong Hui, Weng Yi-Bing, Zhen Gen-Shen, Li Feng-Jie, Jin Ai-Chun, Liu Jie
Emergency Internal Medicine, Beijing Luhe Hospital, Capital Medical University, Beijing, China.
Medicine (Baltimore). 2017 Jun;96(25):e7237. doi: 10.1097/MD.0000000000007237.
This study reports the clinical emergency treatment of 68 critical patients with severe organophosphorus poisoning, and analyzes the prognosis after rescue.The general data of 68 patients with severe organophosphorus poisoning treated in our hospital were retrospectively analyzed. These patients were divided into 2 groups: treatment group, and control group. Patients in the control group received routine emergency treatment, while patients in the treatment group additionally received hemoperfusion plus hemodialysis on the basis of routine emergency treatment. The curative effects in these 2 groups and the prognosis after rescue were compared.Compared with the control group, atropinization time, recovery time of cholinesterase activity, recovery time of consciousness, extubation time, and length of hospital stay were shorter (P < .05); the total usage of atropine was significantly lower (P < .05); Glasgow Coma Score was significantly higher (P < .05); acute physiology and chronic health score (APACHE II) was significantly lower (P < .05); and mortality and poisoning rebound rate was significantly lower (P < .05) in the treatment group.Hemoperfusion and hemodialysis on the basis of routine emergency treatment for critical patients with organophosphorus poisoning can improve rescue outcomes and improve the prognosis of patients, which should be popularized.
本研究报告了68例重症有机磷中毒患者的临床急救治疗情况,并分析了抢救后的预后。回顾性分析了我院收治的68例重症有机磷中毒患者的一般资料。将这些患者分为2组:治疗组和对照组。对照组患者接受常规急救治疗,而治疗组患者在常规急救治疗的基础上还接受血液灌流加血液透析。比较了这2组的疗效及抢救后的预后。与对照组相比,治疗组的阿托品化时间、胆碱酯酶活性恢复时间、意识恢复时间、拔管时间和住院时间更短(P<0.05);阿托品总用量显著更低(P<0.05);格拉斯哥昏迷评分显著更高(P<0.05);急性生理与慢性健康评分(APACHE II)显著更低(P<0.05);治疗组的死亡率和中毒反跳率显著更低(P<0.05)。对重症有机磷中毒患者在常规急救治疗基础上进行血液灌流和血液透析可改善抢救效果,改善患者预后,应予以推广。