College of Engineering, The University of Georgia, 597 D.W. Brooks Drive, Athens, GA, USA.
Department of Cardiology, AU-UGA Medical Partnership, Athens, GA, USA.
Ann Biomed Eng. 2017 Oct;45(10):2298-2308. doi: 10.1007/s10439-017-1878-5. Epub 2017 Jun 22.
Blood flow is a clinical metric for monitoring of cardiovascular diseases but current measurements methods are costly or uncomfortable for patients. It was shown that the interaction of the magnetic field (B ) during MRI and blood flow in the body, through the magnetohydrodynamic (MHD) effect, produce voltages (V ) observable through intra-MRI electrocardiography (ECG), which are correlated with regional blood flow. This study shows the reproducibility of V outside the MRI and its application in a portable flow monitoring device. To recreate this interaction outside the MRI, a static neodymium magnet (0.4T) was placed in between two electrodes to induce the V in a single lead ECG measurement. V was extracted, and integrated over to obtain a stroke volume metric. A smartphone-enabled device utilizing this interaction was developed in order to create a more accessible method of obtaining blood flow measurements. The portable device displayed a <6% error compared to a commercial recorder, and was able to successfully record V using the 0.4T magnet. Exercise stress testing showed a V increase of 23% in healthy subjects, with an 81% increase in the athlete. The study demonstrates a new device utilizing MHD interactions with body circulation to obtain blood flow metrics.
血流是监测心血管疾病的临床指标,但目前的测量方法要么费用高昂,要么让患者感到不适。研究表明,磁共振成像(MRI)过程中磁场(B)与体内血流通过磁流体动力学(MHD)效应相互作用,会产生可通过 MRI 内心电图(ECG)观察到的电压(V),这些电压与局部血流相关。本研究展示了 V 在 MRI 之外的可重复性及其在便携式流量监测设备中的应用。为了在 MRI 之外重现这种相互作用,将一块 0.4T 的钕磁铁放置在两个电极之间,以在单导联 ECG 测量中产生 V。提取 V 并进行积分,以获得一个心搏量指标。为了创造一种更易获得血流测量的方法,开发了一种利用这种相互作用的智能手机设备。该便携式设备与商用记录器相比,误差小于 6%,并且能够成功地使用 0.4T 磁铁记录 V。运动应激测试显示健康受试者的 V 增加了 23%,运动员的 V 增加了 81%。该研究展示了一种利用 MHD 与身体循环相互作用获得血流指标的新设备。