Neuropeptides in human cerebrospinal fluid.
作者信息
Berrettini W H, Nurnberger J I, Gold P W, Chretien M, Chrousos G P, Chan J S, Goldin L R, Gershon E S
出版信息
Life Sci. 1985 Sep 30;37(13):1265-70. doi: 10.1016/0024-3205(85)90139-0.
PMID:2864620
Abstract
Ten neuropeptides were measured by RIA in human cerebrospinal fluid obtained from 30 normal volunteers. The levels of seven peptides (corticotropin releasing factor, adrenocorticotropin, vasoactive intestinal peptide, somatostatin, beta-endorphin, beta-lipotropin, and the N-terminal fragment of proopiomelanocortin) were highly, positively correlated with one another. This result is consistent with the hypothesis that cerebrospinal fluid levels of these seven peptides are a function of some common regulatory factor, such as shared release into the cerebrospinal fluid.
摘要
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