年轻患者的乳腺癌预后
Breast Cancer Prognosis for Young Patients.
作者信息
Owrang Mehdi, Copeland Robert L, Ricks-Santi Luisel J, Gaskins Melvin, Beyene Desta, Dewitty Robert L, Kanaan Yasmine M
机构信息
Department of Computer Science, American University, Washington, DC, U.S.A.
Department of Pharmacology, Howard University, Washington, DC, U.S.A.
出版信息
In Vivo. 2017 Jul-Aug;31(4):661-668. doi: 10.21873/invivo.11109.
BACKGROUND/AIMS: Breast cancer (BCa) prognostication is a vital element for providing effective treatment for patients with BCa. Studies suggest that ethnicity plays a greater role in the incidence and poor prognosis of BCa in younger women than in their older counterparts. Therefore, the goal of this study was to assess the association between age and ethnicity on the overall final prognosis.
MATERIALS AND METHODS
Nottingham Prognostic Index (NPI) was used to analyze BCa prognosis using Howard University Cancer Center Tumor Registry and the National Cancer Institute's Surveillance, Epidemiology, and End Results BCa datasets. Patients were grouped according to their predicted prognosis based on NPI scheme.
RESULTS
There was no correlation between the younger patients compared to their older counterparts for any of the prognostic clusters. The significance of ethnicity in poorer prognosis for younger age is not conclusive either.
CONCLUSION
An extended prognostic tool/system needs to be evaluated for its usefulness in a clinical practice environment.
背景/目的：乳腺癌（BCa）预后评估是为BCa患者提供有效治疗的关键要素。研究表明，种族因素在年轻女性BCa的发病率及不良预后方面比年长女性发挥着更大作用。因此，本研究的目的是评估年龄和种族与总体最终预后之间的关联。
材料与方法
使用诺丁汉预后指数（NPI），通过霍华德大学癌症中心肿瘤登记处以及美国国立癌症研究所的监测、流行病学和最终结果BCa数据集来分析BCa预后。根据NPI方案，将患者按照预测的预后进行分组。
结果
与年长患者相比，年轻患者在任何预后分组中均无相关性。种族因素对年轻患者预后较差的影响也尚无定论。
结论
需要评估一种扩展的预后工具/系统在临床实践环境中的实用性。
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