采用 BODIPY 功能化锆基金属有机骨架对硫芥模拟剂进行解毒。
Detoxification of a Sulfur Mustard Simulant Using a BODIPY-Functionalized Zirconium-Based Metal-Organic Framework.
机构信息
Department of Chemistry, Northwestern University , 2145 Sheridan Road, Evanston, Illinois 60208, United States.
Department of Chemistry, Faculty of Science, King Abdulaziz University , Jeddah 22254, Saudi Arabia.
出版信息
ACS Appl Mater Interfaces. 2017 Jul 26;9(29):24555-24560. doi: 10.1021/acsami.7b05494. Epub 2017 Jul 17.
Effective detoxification of chemical warfare agents is a global necessity. As a powerful photosensitizer, a halogenated BODIPY ligand is postsynthetically appended to the Zr nodes of the metal-organic framework (MOF), NU-1000, to enhance singlet oxygen generation from the MOF. The BODIPY/MOF material is then used as a heterogeneous photocatalyst to produce singlet oxygen under green LED irradiation. The singlet oxygen selectively detoxifies the sulfur mustard simulant, 2-chloroethyl ethyl sulfide (CEES), to the less toxic sulfoxide derivative (2-chloroethyl ethyl sulfoxide, CEESO) with a half-life of approximately 2 min.
有效解毒化学战剂是全球的需要。作为一种强大的光敏剂，卤化 BODIPY 配体被后合成连接到金属有机骨架（MOF）NU-1000 的 Zr 节点上，以增强 MOF 中单线态氧的产生。然后，BODIPY/MOF 材料被用作异相光催化剂，在绿光 LED 照射下产生单线态氧。单线态氧选择性地将硫芥模拟物 2-氯乙基乙基硫醚（CEES）解毒为毒性较小的亚砜衍生物（2-氯乙基乙基亚砜，CEESO），半衰期约为 2 分钟。
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