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动态过伸支具对绝经后骨质疏松症女性骨质疏松及脊柱后凸改善的影响

The Effect of Dynamic Hyperextension Brace on Osteoporosis and Hyperkyphosis Reduction in Postmenopausal Osteoporotic Women.

作者信息

Shariatzadeh Hooman, Modaghegh Bagher Saeed, Mirzaei Alireza

机构信息

Bone and Joint Reconstruction Research Center, Shafa Orthopedic Hospital, Iran University of Medical Sciences, Tehran, Iran.

出版信息

Arch Bone Jt Surg. 2017 May;5(3):181-185.

Abstract

BACKGROUND

Osteoporosis and hyperkyphosis could impose a considerable financial and therapeutic burden on the affected society. Thus, new strategies to prevent or manage such complications are of significant importance. Here we evaluate the effect of 'Dynamic Hyperextension Brace' (DHB) on bone density, and hyperkyphosis correction.

METHODS

Sixty postmenopausal women were randomly assigned to the case and control groups and followed for one year. DHB was applied in the case group according to the pre-designed protocol and the patients' clinical and paraclinical parameters, including bone mineral density (BMD), kyphosis angle, osteoporotic fracture, and serum alkaline phosphatase (ALP) were evaluated in two groups.

RESULTS

Despite no significant difference in basic BMD and kyphosis between the case and control groups, BMD and kyphosis were significantly improved in the DHB treated group, at the end of the study (P=0.003 and P=0.001, respectively). Serum ALP level was significantly higher in cases compared to the controls (P=0.48). The vertebral fracture rate was also lower in the case group compared to the controls.

CONCLUSION

The efficacy of bracing in osteoporosis and kyphosis management should be more emphasized. However, more detailed and controlled studies with more patients and a longer follow-up period is needed to adequately evaluate the long-term results of braces, including DHB.

摘要

背景

骨质疏松症和脊柱后凸畸形会给受影响的社会带来相当大的经济和治疗负担。因此,预防或管理此类并发症的新策略具有重要意义。在此,我们评估“动态伸展支具”(DHB)对骨密度和脊柱后凸矫正的效果。

方法

60名绝经后女性被随机分为病例组和对照组,并随访1年。病例组根据预先设计的方案使用DHB,评估两组患者的临床和辅助临床参数,包括骨密度(BMD)、脊柱后凸角度、骨质疏松性骨折和血清碱性磷酸酶(ALP)。

结果

尽管病例组和对照组之间的基础骨密度和脊柱后凸无显著差异,但在研究结束时,DHB治疗组的骨密度和脊柱后凸得到显著改善(分别为P = 0.003和P = 0.001)。病例组血清ALP水平显著高于对照组(P = 0.48)。病例组的椎体骨折率也低于对照组。

结论

应更加强调支具在骨质疏松症和脊柱后凸治疗中的疗效。然而,需要更详细、有对照的研究,纳入更多患者并延长随访期,以充分评估支具(包括DHB)的长期效果。

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