Bradley Megan S, Bickhaus Jennifer A, Amundsen Cindy L, Newcomb Laura K, Truong Tracy, Weidner Alison C, Siddiqui Nazema Y
Female Pelvic Med Reconstr Surg. 2018 May/Jun;24(3):207-212. doi: 10.1097/SPV.0000000000000451.
The aim of this study was to compare anatomic results after vaginal uterosacral ligament suspension with absorbable versus permanent suture.
We performed a retrospective cohort study of women who underwent vaginal uterosacral ligament suspension, from 2006 to 2015. We compared 2 groups: (1) absorbable suspension suture and (2) permanent suspension suture (even if accompanied by absorbable suture). Our primary outcome was composite anatomic failure defined as (1) recurrent prolapse in any compartment past the hymen or (2) retreatment for prolapse. Continuous variables were analyzed using the Student t test or Mann-Whitney U test, and categorical variables were analyzed using χ or Fisher exact test. Multivariable logistic regression analysis was performed to control for confounders. P < 0.05 was considered significant.
Of the 242 patients with medium-term follow-up (3 months to 2 years after surgery), 188 underwent vaginal uterosacral ligament suspension with only absorbable suture, and 54 underwent suspension with permanent suture. Compared with the absorbable suture cohort, the permanent suture cohort was more likely to have had advanced preoperative prolapse (P = 0.01), less likely to have had a prior hysterectomy (P = 0.01), and less likely to have undergone a concomitant posterior colporrhaphy/perineoplasty (P < 0.01). Overall, there were no differences in composite anatomic failure between the absorbable and permanent suture groups (17.0% vs 20.4%, P = 0.41). In multivariable logistic regression analyses, when controlling for covariates, there remained no difference in composite anatomic failure between permanent and absorbable suture groups.
Completion of vaginal uterosacral ligament suspension using only absorbable suture affords similar anatomic outcomes in the medium term as compared with suspension with additional permanent suture.
本研究旨在比较使用可吸收缝线与永久性缝线进行阴道骶韧带悬吊术后的解剖学结果。
我们对2006年至2015年间接受阴道骶韧带悬吊术的女性进行了一项回顾性队列研究。我们比较了两组:(1)可吸收悬吊缝线组和(2)永久性悬吊缝线组(即使伴有可吸收缝线)。我们的主要结局是复合解剖学失败,定义为:(1)处女膜外任何腔室复发脱垂或(2)因脱垂再次治疗。连续变量采用Student t检验或Mann-Whitney U检验进行分析,分类变量采用χ²检验或Fisher精确检验进行分析。进行多变量逻辑回归分析以控制混杂因素。P < 0.05被认为具有统计学意义。
在242例接受中期随访(术后3个月至2年)的患者中,188例仅使用可吸收缝线进行了阴道骶韧带悬吊术,54例使用永久性缝线进行了悬吊术。与可吸收缝线组相比,永久性缝线组术前脱垂程度更严重的可能性更大(P = 0.01),既往行子宫切除术的可能性更小(P = 0.01),同时行后阴道壁修补术/会阴成形术的可能性更小(P < 0.01)。总体而言,可吸收缝线组和永久性缝线组在复合解剖学失败方面没有差异(17.0%对20.4%,P = 0.41)。在多变量逻辑回归分析中,在控制协变量后,永久性缝线组和可吸收缝线组在复合解剖学失败方面仍然没有差异。
与额外使用永久性缝线进行悬吊相比,仅使用可吸收缝线完成阴道骶韧带悬吊术在中期可获得相似的解剖学结果。