Valet Maxime, Lejeune Thierry, Glibert Yumiko, Hakizimana Jean C, Van Pesch Vincent, El Sankari Souraya, Detrembleur Christine, Stoquart Gaëtan
aUniversité catholique de Louvain, Secteur des Sciences de la Santé, Institut de Recherche Expérimentale et Clinique, Neuromusculoskeletal Lab (NMSK) bCliniques universitaires Saint-Luc, Service de Médecine Physique et Réadaptation cCliniques universitaires Saint-Luc, Service de Neurologie, Brussels, Belgium.
Int J Rehabil Res. 2017 Sep;40(3):268-274. doi: 10.1097/MRR.0000000000000238.
Fatigue is frequent and disabling in persons with multiple sclerosis (pwMS) with mild neurological disability. These patients also have impaired physical fitness. Whether mildly disabled pwMS are deconditioned, and this deconditioning is linked to fatigue, remains unknown. Our aim is to determine the physical fitness of mildly disabled patients with multiple sclerosis and study its relationship with perceived fatigue and to link perceived fatigue with other parameters. Twenty patients (14 women; mean age: 45.5 years) with mild disability (Expanded Disability Status Scale 0-4) underwent a 2-min walking test, Timed Up-and-Go test, aerobic capacity testing, and isometric knee extension testing to assess strength and neuromuscular fatigability. They completed questionnaires assessing perceived fatigue, psychological status, and physical activity. Correlation coefficients and multivariate regression were used to analyze the relationships among variables. Seventeen (85%) patients reported a high level of fatigue. Thirteen (65%) patients had subnormal aerobic capacity. Fatigue was weakly to moderately associated with aerobic capacity, mobility, walking capacity, depression, and neuromuscular fatigability. An association of disease duration, aerobic capacity, and the neuromuscular fatigability index explained 65.1% of fatigue. A high proportion of pwMS with mild neurological disability are fatigued and deconditioned. Perceived fatigue is linked to aerobic capacity, neuromuscular fatigability, depression, mobility, and walking capacity. Focusing on these parameters could help in the management of fatigue.
疲劳在轻度神经功能障碍的多发性硬化症患者（pwMS）中很常见且会导致功能丧失。这些患者的身体素质也有所下降。轻度残疾的pwMS是否存在身体机能减退，以及这种身体机能减退是否与疲劳有关，目前尚不清楚。我们的目的是确定轻度残疾的多发性硬化症患者的身体素质，研究其与感知疲劳的关系，并将感知疲劳与其他参数联系起来。20名轻度残疾（扩展残疾状态量表0 - 4级）的患者（14名女性；平均年龄：45.5岁）接受了2分钟步行测试、定时起立行走测试、有氧能力测试和等长膝关节伸展测试，以评估力量和神经肌肉疲劳性。他们完成了评估感知疲劳、心理状态和身体活动的问卷。使用相关系数和多元回归分析变量之间的关系。17名（85%）患者报告有高度疲劳。13名（65%）患者有氧能力低于正常水平。疲劳与有氧能力、活动能力、步行能力、抑郁和神经肌肉疲劳性呈弱至中度相关。病程、有氧能力和神经肌肉疲劳性指数之间的关联解释了65.1%的疲劳情况。很大一部分轻度神经功能障碍的pwMS患者存在疲劳和身体机能减退。感知疲劳与有氧能力、神经肌肉疲劳性、抑郁、活动能力和步行能力有关。关注这些参数可能有助于疲劳的管理。
