Rana Anil Kumar Singh, Agarwal Nitin, Dutta Sushant, Dokania Manoj Kumar
Department of Surgery, Postgraduate Institute of Medical Education and Research (PGIMER) and Dr. Ram Manohar Lohia Hospital, Baba Kharak Singh Marg, Delhi, 110001 India.
Indian J Surg. 2017 Jun;79(3):262-265. doi: 10.1007/s12262-016-1549-z. Epub 2016 Aug 20.
Efforts to increase the dismal deceased renal transplantation (DRT): live renal transplantation (LRT) ratio in our country have gathered momentum recently, with governmental and non-governmental projects focussing on building public awareness and capacity-building, and appropriate legislation. Worldwide, efforts at increasing the number of organs from the deceased pool have focussed on the use of 'expanded criteria donors', including deceased cardiac donors (DCD). 'Reuse' transplant, where an organ is transplanted after removal from the first recipient, is a rare strategy, used more commonly in liver than in kidney transplantation. Exceptional circumstances, where other organs have been harvested from transplant recipients, are rare. We describe the successful transplants of two renal grafts obtained from a 19-year-old brain-dead liver transplant recipient; this is probably the second case in English-language literature. A 19-year-old male patient with hepatitis E-induced fulminant hepatic failure underwent live-related liver transplantation. On postoperative day 2, cerebral edema set in, and the patient was declared brain-dead. Despite the economical and emotional trauma, the family opted for donation of the well-perfused kidneys. The kidneys were transported in HTK solution (histidine-tryptophan-ketoglutarate) to our centre. Recipient 1 was a 32-year-old woman (B positive) and recipient 2 was a 29-year-old man (also B positive); the kidneys were placed extraperitoneally and anastomosed end-to-side to the external iliac artery and vein. Recipient 2 experienced delayed graft function; however, both are doing well 15 months posttransplant.
我国为提高极低的尸体肾移植(DRT)与活体肾移植(LRT)比例所做的努力最近有了新进展,政府和非政府项目致力于提高公众意识、开展能力建设并制定适当立法。在全球范围内,为增加尸体器官数量所做的努力主要集中在使用“扩大标准供体”,包括心脏死亡供体(DCD)。“再利用”移植是一种罕见的策略,即器官从首位受者身上取出后再进行移植,在肝移植中比肾移植中更常用。从移植受者身上摘取其他器官的特殊情况很少见。我们描述了从一名19岁脑死亡肝移植受者身上获取的两枚肾移植成功的案例;这可能是英文文献中的第二例。一名19岁男性患者因戊型肝炎导致暴发性肝衰竭,接受了亲属活体肝移植。术后第2天,患者出现脑水肿,随后被宣布脑死亡。尽管遭受了经济和情感上的创伤,患者家属仍选择捐赠灌注良好的肾脏。肾脏用HTK溶液(组氨酸 - 色氨酸 - 酮戊二酸)运送至我们中心。受者1是一名32岁女性(B阳性),受者2是一名29岁男性(也是B阳性);肾脏置于腹膜外,端侧吻合至髂外动脉和静脉。受者2出现移植肾功能延迟;然而,两名受者在移植后15个月情况都良好。