Stjärne L, Alberts P
Acta Physiol Scand. 1985 Oct;125(2):181-94. doi: 10.1111/j.1748-1716.1985.tb07706.x.
In guinea-pig isolated vas deferens moderate cooling (within the range 16-41 degrees C) improved, while further cooling depressed, sympathetic neuromuscular transmission. Moderate cooling: (a) enhanced the contractile responses both to electrical nerve stimulation and (although less strongly) to exogenous noradrenaline or to the adenosine 5'-triphosphate (ATP) analogue, alpha, beta-methylene ATP; (b) enhanced the overflow of [3H]noradrenaline evoked by electrical nerve stimulation at 1-8 Hz, but not that caused by direct depolarization of varicosities with 80 mM potassium; (c) reduced the depressing effect of exogenous noradrenaline, as well as the enhancing effect of the alpha-adrenoceptor blocking agent phentolamine, on the secretory responses to electrical nerve stimulation; (d) while not altering the maximal secretion of tracer noradrenaline at infinitely high frequency or external calcium, lowered the frequency or calcium concentration required for half-maximal secretion, both in the absence and in the presence of phentolamine.
moderate cooling improves sympathetic neuromuscular transmission in guinea-pig vas deferens, both prejunctionally, by enhancing transmitter secretion, and post-junctionally, by increasing the responsiveness of the smooth muscle to transmitter.
在豚鼠离体输精管中，适度冷却（16 - 41摄氏度范围内）可改善交感神经肌肉传递，而进一步冷却则会抑制该传递。适度冷却：(a) 增强对电刺激神经以及（虽然程度较弱）对外源性去甲肾上腺素或腺苷5'-三磷酸（ATP）类似物α,β-亚甲基ATP的收缩反应；(b) 增强1 - 8赫兹电刺激神经诱发的[3H]去甲肾上腺素溢出，但不增强用80 mM钾使曲张体直接去极化所引起的溢出；(c) 降低外源性去甲肾上腺素的抑制作用以及α-肾上腺素能受体阻断剂酚妥拉明对电刺激神经分泌反应的增强作用；(d) 虽然不改变在无限高频率或外部钙存在时示踪去甲肾上腺素的最大分泌量，但在不存在和存在酚妥拉明的情况下，均降低达到最大分泌量一半所需的频率或钙浓度。
适度冷却可改善豚鼠输精管中的交感神经肌肉传递，在节前通过增强递质分泌，在节后通过增加平滑肌对递质的反应性来实现。
