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立体定向引导下的乳腺病变切除系统(BLES)不能作为切除乳腺微小钙化小区域的治疗工具。

The breast lesion excision system (BLES) under stereotactic guidance cannot be used as a therapeutic tool in the excision of small areas of microcalcifications in the breast.

作者信息

Milos Ruxandra-Iulia, Bernathova Maria, Baltzer Pascal A, Pinker-Domenig Katja, Kapetas Panagiotis, Rudas Margaretha, Helbich Thomas H

机构信息

Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Austria.

Department of Clinical Pathology, Medical University of Vienna, Austria.

出版信息

Eur J Radiol. 2017 Aug;93:252-257. doi: 10.1016/j.ejrad.2017.05.045. Epub 2017 Jun 2.

Abstract

OBJECTIVE

The breast lesion excision system (BLES) is a new, automatic percutaneous breast biopsy device that excises single large specimens using radiofrequency cutting. The aim of this study was to determine whether BLES, under stereotactic guidance, can be used as a therapeutic tool in the assessment of small areas of microcalcifications in the breast by providing samples with clear margins.

MATERIAL AND METHODS

In this retrospective study, 149 patients with suspicious (BIRADS 4 or 5) small areas of microcalcifications underwent stereotactic-guided BLES. Of these, 34 patients (22.8%) with microcalcifications that had a diameter smaller than the basket size (≤15mm) underwent both BLES and subsequent surgery. Histopathology findings from BLES and subsequent surgery were compared. Identical, underestimation and total excision findings were assessed.

RESULTS

BLES revealed fourteen (41.1%) high-risk lesions, ten (29.4%) ductal carcinomas in situ, and ten (29.4%) invasive cancers. Identical results between BLES and surgery were seen in 17/34 (50%) lesions. Surgery confirmed total excision of BLES in 15/34 (44.1%) lesions. Underestimation was seen in 2/34 (5.8%) lesions.

CONCLUSION

BLES allows accurate diagnosis of small areas of microcalcifications, with few underestimates. BLES is a diagnostic, but cannot be considered to be a therapeutic tool in the case of suspicious microcalcifications because total excision was seen in only 44.1% of these lesions. Studies are needed to address the therapeutic benefit of this procedure in solid lesions.

摘要

目的

乳腺病变切除系统(BLES)是一种新型的自动经皮乳腺活检设备,它利用射频切割技术切除单个大标本。本研究的目的是确定在立体定向引导下,BLES能否通过提供具有清晰边缘的样本,作为评估乳腺微小钙化小区域的治疗工具。

材料与方法

在这项回顾性研究中,149例有可疑(乳腺影像报告和数据系统4类或5类)微小钙化小区域的患者接受了立体定向引导下的BLES。其中,34例(22.8%)微小钙化直径小于篮筐尺寸(≤15mm)的患者接受了BLES及后续手术。比较了BLES和后续手术的组织病理学结果。评估了结果一致、低估和完全切除的情况。

结果

BLES显示14例(41.1%)高危病变、10例(29.4%)导管原位癌和10例(29.4%)浸润性癌。在17/34(50%)的病变中,BLES和手术结果一致。手术证实15/34(44.1%)的病变BLES已完全切除。2/34(5.8%)的病变存在低估情况。

结论

BLES能够准确诊断微小钙化小区域,低估情况较少。BLES是一种诊断工具,但对于可疑微小钙化病例不能被视为治疗工具,因为这些病变中只有44.1%实现了完全切除。需要开展研究以探讨该方法在实性病变中的治疗益处。

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