Milos Ruxandra-Iulia, Bernathova Maria, Baltzer Pascal A, Pinker-Domenig Katja, Kapetas Panagiotis, Rudas Margaretha, Helbich Thomas H
Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Austria.
Department of Clinical Pathology, Medical University of Vienna, Austria.
Eur J Radiol. 2017 Aug;93:252-257. doi: 10.1016/j.ejrad.2017.05.045. Epub 2017 Jun 2.
The breast lesion excision system (BLES) is a new, automatic percutaneous breast biopsy device that excises single large specimens using radiofrequency cutting. The aim of this study was to determine whether BLES, under stereotactic guidance, can be used as a therapeutic tool in the assessment of small areas of microcalcifications in the breast by providing samples with clear margins.
In this retrospective study, 149 patients with suspicious (BIRADS 4 or 5) small areas of microcalcifications underwent stereotactic-guided BLES. Of these, 34 patients (22.8%) with microcalcifications that had a diameter smaller than the basket size (≤15mm) underwent both BLES and subsequent surgery. Histopathology findings from BLES and subsequent surgery were compared. Identical, underestimation and total excision findings were assessed.
BLES revealed fourteen (41.1%) high-risk lesions, ten (29.4%) ductal carcinomas in situ, and ten (29.4%) invasive cancers. Identical results between BLES and surgery were seen in 17/34 (50%) lesions. Surgery confirmed total excision of BLES in 15/34 (44.1%) lesions. Underestimation was seen in 2/34 (5.8%) lesions.
BLES allows accurate diagnosis of small areas of microcalcifications, with few underestimates. BLES is a diagnostic, but cannot be considered to be a therapeutic tool in the case of suspicious microcalcifications because total excision was seen in only 44.1% of these lesions. Studies are needed to address the therapeutic benefit of this procedure in solid lesions.
乳腺病变切除系统(BLES)是一种新型的自动经皮乳腺活检设备,它利用射频切割技术切除单个大标本。本研究的目的是确定在立体定向引导下,BLES能否通过提供具有清晰边缘的样本,作为评估乳腺微小钙化小区域的治疗工具。
在这项回顾性研究中,149例有可疑(乳腺影像报告和数据系统4类或5类)微小钙化小区域的患者接受了立体定向引导下的BLES。其中,34例(22.8%)微小钙化直径小于篮筐尺寸(≤15mm)的患者接受了BLES及后续手术。比较了BLES和后续手术的组织病理学结果。评估了结果一致、低估和完全切除的情况。
BLES显示14例(41.1%)高危病变、10例(29.4%)导管原位癌和10例(29.4%)浸润性癌。在17/34(50%)的病变中,BLES和手术结果一致。手术证实15/34(44.1%)的病变BLES已完全切除。2/34(5.8%)的病变存在低估情况。
BLES能够准确诊断微小钙化小区域,低估情况较少。BLES是一种诊断工具,但对于可疑微小钙化病例不能被视为治疗工具,因为这些病变中只有44.1%实现了完全切除。需要开展研究以探讨该方法在实性病变中的治疗益处。