心脏移植受者左心室灌注缺损与心肌形变指标之间的关联
Association between left ventricular perfusion defects and myocardial deformation indexes in heart transplantation recipients.
作者信息
D'Andrea Antonello, De Rimini Maria Luisa, America Raffaella, Cirillo Chiara, Riegler Lucia, Limongelli Giuseppe, D'Alto Michele, Salerno Gemma, Maiello Ciro, Muto Pietro, Russo Maria Giovanna, Calabrò Raffaele, Bossone Eduardo, Pacileo Giuseppe
机构信息
Chair of Cardiology, Monaldi Hospital, AORN Ospedali dei Colli, Luigi Vanvitelli University of Naples, Naples, Italy.
Department of Nuclear Medicine, Monaldi Hospital, AORN Ospedali dei Colli, Naples, Italy.
出版信息
Echocardiography. 2017 Oct;34(10):1540-1543. doi: 10.1111/echo.13596. Epub 2017 Jul 3.
The aim of the study was to analyze possible correlations between strain echocardiography (STE) and PET myocardial perfusion in a population of heart transplantation (HTx) recipients showing preserved left ventricular (LV) ejection fraction. By STE, LV global longitudinal strain (LV GLS) was lower in HTx. PET showed no transient or chronic ischemia in 83 of 115 HTx (73%). Fixed perfusion defects were observed in 17% of HTx and reversible ischemia in 10%. Significant coronary stenosis was observed only in 10 cases. GLS was independently associated with age at HTx and fixed perfusion defects (HR 0.41; P<.001). Such relationships underline STE ability to early identify HTx pts with subclinical myocardial dysfunction during long-term follow-up.
本研究的目的是分析应变超声心动图（STE）与正电子发射断层扫描（PET）心肌灌注之间的可能相关性，研究对象为左心室（LV）射血分数保留的心脏移植（HTx）受者群体。通过STE检测发现，HTx受者的左心室整体纵向应变（LV GLS）较低。PET显示，115例HTx受者中有83例（73%）无短暂性或慢性缺血。17%的HTx受者观察到固定灌注缺损，10%的受者观察到可逆性缺血。仅在10例患者中观察到明显的冠状动脉狭窄。GLS与HTx时的年龄和固定灌注缺损独立相关（风险比0.41；P<0.001）。这些关系强调了STE在长期随访中早期识别亚临床心肌功能障碍的HTx患者的能力。
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