Estrada-Martínez Laura Elena, Moreno-Celis Ulisses, Cervantes-Jiménez Ricardo, Ferriz-Martínez Roberto Augusto, Blanco-Labra Alejandro, García-Gasca Teresa
Facultad de Ciencias Naturales, Universidad Autónoma de Querétaro, Santiago de Querétaro 76230, Querétaro, Mexico.
Unidad de Bioquímica y Biotecnología de Plantas, CINVESTAV Unidad Irapuato, Irapuato 36821, Guanajuato, Mexico.
Int J Mol Sci. 2017 Jul 3;18(7):1403. doi: 10.3390/ijms18071403.
Digestive system cancers-those of the esophagus, stomach, small intestine, colon-rectum, liver, and pancreas-are highly related to genetics and lifestyle. Most are considered highly mortal due to the frequency of late diagnosis, usually in advanced stages, caused by the absence of symptoms or masked by other pathologies. Different tools are being investigated in the search of a more precise diagnosis and treatment. Plant lectins have been studied because of their ability to recognize and bind to carbohydrates, exerting a variety of biological activities on animal cells, including anticancer activities. The present report integrates existing information on the activity of plant lectins on various types of digestive system cancers, and surveys the current state of research into their properties for diagnosis and selective treatment.
消化系统癌症,即食管癌、胃癌、小肠癌、结直肠癌、肝癌和胰腺癌,与遗传和生活方式高度相关。由于缺乏症状或被其他病症掩盖,大多数消化系统癌症通常在晚期才被诊断出来,因此死亡率很高。目前正在研究不同的工具以寻求更精确的诊断和治疗方法。植物凝集素因其能够识别并结合碳水化合物,对动物细胞发挥多种生物活性,包括抗癌活性而受到研究。本报告整合了关于植物凝集素对各类消化系统癌症活性的现有信息,并调查了其用于诊断和选择性治疗的特性的研究现状。