通过高价碘直接α-氧化N-苯甲酰基氨基酸合成4-乙酰氧基5（4H）-恶唑酮的新方法。
A Novel Synthesis of 4-Acetoxyl 5(4H)-Oxazolones by Direct α-Oxidation of N-Benzoyl Amino-Acid Using Hypervalent Iodine.
作者信息
Wen Gang, Zhang Wen-Xuan, Wu Song
机构信息
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
出版信息
Molecules. 2017 Jul 3;22(7):1102. doi: 10.3390/molecules22071102.
We have developed a new method to prepare 4-acetoxy substituted 5(4)-oxazolones by direct oxidation of -benzoyl amino-acids using hypervalent iodine. The method is efficient, economical and easy to perform for the synthesis of quaternary substituted amino acid derivatives. We used online FTIR monitoring techniques to analyze the reaction, and gave a plausible reaction mechanism.
我们已经开发出一种新方法，通过使用高价碘直接氧化α-苯甲酰基氨基酸来制备4-乙酰氧基取代的5(4)-恶唑酮。该方法对于合成季铵取代的氨基酸衍生物而言高效、经济且易于操作。我们使用在线傅里叶变换红外光谱监测技术来分析该反应，并给出了一个合理的反应机理。
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