Singh Gagandeep, Sharma Ravina
Department of Neurology, Dayanand Medical College, Ludhiana, India.
Department of Neurology, Dayanand Medical College, Ludhiana, India.
Epilepsy Behav. 2017 Nov;76:163-167. doi: 10.1016/j.yebeh.2017.05.033. Epub 2017 Jun 30.
Seizures are the commonest manifestation of brain parenchymal cysticercosis. In terms of pathophysiological basis and prognostic significance of the seizures, a distinction might be applied between viable cysts, solitary cysticercus granuloma and calcific cysticerci. A number of uncertainties shroud the management of seizures in people with neurocysticercosis (NCC). Although antihelminthic treatment is effective in eliminating viable cysts and possibly cysticercus granulomas, its effect on seizure outcome remains uncertain. Corticosteroids and combinations of antihelminthic and corticosteroid treatments reduce the incidence of seizures in the short term at least. Although antiepileptic drugs (AEDs) are routinely employed in the treatment of seizures associated with NCC, there is no clear consensus regarding the choice and optimal duration of AED treatment. Long-term AED treatment is warranted in people with calcific residue following involution of brain parenchymal cysticercosis. This article is part of a Special Issue entitled "Neurocysticercosis and Epilepsy".
癫痫发作是脑实质囊尾蚴病最常见的表现形式。就癫痫发作的病理生理基础和预后意义而言，可对活囊肿、孤立性囊尾蚴肉芽肿和钙化囊尾蚴进行区分。神经囊尾蚴病（NCC）患者癫痫发作的管理存在诸多不确定性。尽管抗蠕虫治疗在消除活囊肿以及可能的囊尾蚴肉芽肿方面有效，但其对癫痫发作结局的影响仍不确定。皮质类固醇以及抗蠕虫药与皮质类固醇联合治疗至少在短期内可降低癫痫发作的发生率。尽管抗癫痫药物（AEDs）常规用于治疗与NCC相关的癫痫发作，但关于AED治疗的选择和最佳疗程尚无明确共识。脑实质囊尾蚴病 involution 后有钙化残留的患者需要长期进行AED治疗。本文是名为“神经囊尾蚴病与癫痫”的特刊的一部分。 （注：原文中“involution”这个词在医学语境下结合前文推测可能是“消退”之类的意思，但结合整个翻译来看，此处翻译似乎不太完整准确，原文可能存在表述不太清晰的问题。不过按照要求，严格按原文翻译了。）
